Jun 30, 2017 · Methods: Ovine fetuses were intra-amniotically exposed to chronic Ureaplasma parvum (UP) at 24 days (d) before extreme preterm delivery at 94d (term 147d) and/or to lipopolysaccharide (LPS) 7 or 2d before delivery. Pulmonary inflammation, vascular remodeling and angiogenic factors were assessed.

We aimed to establish how chorioamnionitis affects contractile function and phenotype of the preterm diaphragm. Pregnant ewes received intra-amniotic injections of saline or 10 mg lipopolysaccharide (LPS) 2d or 7d prior to delivery at 121d gestation (term = 150d).

Feb 2, 2012 · Representative photomicrographs of immunostaining against myeloperoxidase using lung sections from controls (B), 14d betamethasone + 7d LPS (C), and 14d LPS + 7d betamethasone (D). MPO-positive cells increased in the lung tissue 14 days after LPS exposure compared with controls.

Feb 21, 2021 · Pre-exposure to UP attenuated neutrophil infiltration in 7d LPS-exposed lungs and prevented reduction of SOX-9 expression and increased SP-B expression, which could indicate protective responses induced by re-exposure.

To study the impact of sustained inflammation on glucose homeostasis, we devised a model whereby mice were given daily i.p. injections of low-dose LPS for 7 days (7D-LPS), or PBS as a control. 7D-LPS treatment induced fasting hyperglycemia and hyperinsulinemia without any effect on body weight .

Dec 9, 2011 · Time-mated ewes with singleton fetuses received an intra-amniotic injection of lipopolysaccharide (LPS) either preceding or following maternal intramuscular betamethasone 7 or 14 days before...

LPS of higher concentrations (4 and 10 mg/sac vs. 0.1 and 1 mg/sac) and a shorter duration (2 d vs. 7 d) elicited more profound cytokine responses and recruited more inflammatory cells in the...

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Representative images are shown for Club cells in saline (D), 2d LPS (E) and UP + 2d LPS (F) groups, and for AEC2 in saline (G), UP (H) and UP+2d LPS (I) animals.

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