Mar 30, 2025 · THAP4 (THAP Domain Containing 4) is a Protein Coding gene. Diseases associated with THAP4 include Venous Hemangioma and Chromosome 2Q37 Deletion Syndrome. Among its related pathways is 2q37 copy number variation syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

The C-terminal domain of THAP4 (residues 415-577), designated here as cTHAP4, is evolutionarily conserved and is observed in all know THAP4 orthologues. Several single domain proteins lacking a THAP domain are found in plants and bacteria, and show significant levels of homology to cTHAP4.

Mar 5, 2019 · In this study, we explore the possibility of oligomerization of THAP proteins by predicting a coiled coil region in a ~ 40 amino acid leucine rich region that is located downstream of the highly conserved DNA-binding THAP domain.

Many members of the THAP family act as transcription factors that control cell proliferation, cell cycle progression, angiogenesis, apoptosis and epigenetic gene silencing. They recognize specific DNA sequences in the promoters of target genes and …

Jan 7, 2024 · Structure of the C-terminal heme-binding domain of THAP domain containing protein 4 from Homo sapiens. Voxelwise genome-wide association study (vGWAS).

Feb 9, 2025 · peroxynitrite isomerase THAP4, THAP domain-containing protein 4, epididymis secretory sperm binding protein, ferric Homo sapiens nitrobindin, hs-Nb (III), nitrobindin. Enables several functions, including heme binding activity; nitric oxide binding activity; and peroxynitrite isomerase activity.

Apr 1, 2011 · Human THAP4 is a 577-residue protein of unknown function that is proposed to bind DNA in a sequence-specific manner similar to THAP1 and has been found to be upregulated in response to heat...

Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein (s) are secreted or actually retained in intracellular locations or membrane-attached.

The gene view histogram is a graphical view of mutations across THAP4. These mutations are displayed at the amino acid level across the full length of the gene by default.

By searching databases, Roussigne et al. (2003) identified several proteins containing an N-terminal THAP domain, including THAP4. The THAP domain of the deduced 577-amino acid THAP4 protein includes a C2CH signature, an AVPTIF box, …