T h 17 cells play an important role in maintaining mucosal barriers and contributing to pathogen clearance at mucosal surfaces; such protective and non-pathogenic T h 17 cells have been termed as T reg 17 cells. [2] They have also been implicated in autoimmune and …

Recent data in humans and mice suggest that Th17 cells play an important role in the pathogenesis of a diverse group of immune-mediated diseases, including psoriasis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and asthma. Initial reports also propose a role for Th17 cells in tumorigenesis and transplant rejection.

The effector function of CD4 + T helper cells is mediated primarily by secreted cytokines, and the specific cytokine profile produced by each subset has been one of the main defining characteristics uses to phenotype each population [] (Figure 2).Th17 cells were the first subset identified as distinct from the original Th1/Th2 paradigm that had persisted for decades and …

Jan 3, 2023 · In this Review, we discuss the heterogeneity of T H 17 cells and the role of this heterogeneity in diverse functions of T H 17 cells from homeostasis to tissue inflammation.

They assist B cells to make antibodies, activate the microbe killing capacity of macrophages and recruit other immune cells to infected or inflamed areas of the body. These activities are orchestrated through their production of various cytokines and chemokines.

A third subset of IL-17-producing effector T helper cells, called Th17 cells, has now been discovered and characterized. Here, we summarize the current information on the differentiation and effector functions of the Th17 lineage.

Initial studies in humans have confirmed the existence of Th17 cells, but they have shown that the origin of these cells in humans differs from that in mice, with IL-1β and IL-23 being the major cytokines responsible for their development.

Th17 cells have earned a well-deserved reputation as key modulators in autoimmunity; however, the Th17 lineage has pleiotropic effects on a variety of cell types including epithelial, endothelial, and fibroblastic cells . The Th17 lineage provides a unique mechanism for protection against bacterial and fungal pathogens through production and ...

Sep 27, 2021 · CD4 + T helper (T H) cells produce cytokines to regulate immune responses; T H 1 cells and T H 2 cells, which were discovered in the 1980s, have important roles in regulating immune responses to...

Apr 7, 2025 · Th17 cells are characterized by their capacity to secrete IL-17A, IL-17F, IL-21, IL-22, and CCL20. Th17 cells develop from naïve CD4+ T cells in the presence of TGF-β and IL-6.