CCR4 Involvement in the Expansion of T Helper Type 17 Cells in
Psoriasis is a chronic skin disease associated with T helper (Th)17-mediated inflammation. Because CCR4 is a major chemokine receptor expressed on Th17 cells, we investigated the …
CCR4 plays a pivotal role in Th17 cell recruitment and ... - PubMed
Dec 31, 2022 · Th17 cells are known to play a critical role in the pathogenesis of rheumatoid arthritis (RA). CCL22 has also been shown to be up-regulated in the synovial tissues of RA …
Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T Cells …
We propose a model in which CCR4 + CCR6 + Th17 and CXCR3 + CCR6 + Th1Th17 T cells significantly contribute to HIV-1 pathogenesis by their ability to promote viral replication and …
CCR4 as a Therapeutic Target for Cancer Immunotherapy - PMC
CCR4 is a chemokine receptor mainly expressed by T cells. It is the receptor for two CC chemokine ligands, CCL17 and CCL22. Originally, the expression of CCR4 was described as …
Cytokine‐regulated Th17 plasticity in human health and diseases
Classical Th17 cells can be isolated ex vivo (through CD161, CCR6 and CCR4) from blood and tissue of healthy individuals or generated in vitro in response to Staphylococcus aureus (S. …
T helper (Th) cell profiles and cytokines/chemokines in ...
Dec 1, 2023 · Our findings of Th cell-subsets by flow cytometry and cytokines/chemokines by multiplex ELISA suggest that CCR6 + Th cell-subsets (Th17, Th17.1, Th22, and Th9) …
Human CCR4+ CCR6+ Th17 cells suppress autologous CD8+ T …
Jun 15, 2012 · We show a novel function for a subset of IL-17-secreting CD4(+) T cells, namely, CCR4(+)CCR6(+)Th17 cells. When cultured together, CCR4(+)CCR6(+)Th17 cells …
A Narrative Review of the State of the Art of CCR4-Based ... - MDPI
Apr 22, 2024 · Their findings indicate that CCR4 is critically involved in regional lymph node DC-Th17 cell interactions that are necessary for Th17 cell-mediated induction of antitumour CD8 + …
The intrinsic expression of NLRP3 in Th17 cells promotes their
Apr 7, 2025 · Th17 cells can perform either regulatory or inflammatory functions depending on the cytokine microenvironment. ... as assessed by the membrane markers CCR4, CCR8, CD137, …
Human CCR4+CCR6+Th17 Cells Suppress Autologous CD8+ T …
Jun 15, 2012 · We show a novel function for a subset of IL-17–secreting CD4 + T cells, namely, CCR4 + CCR6 + Th17 cells. When cultured together, CCR4 + CCR6 + Th17 cells suppressed …