Mar 13, 2025 · It was found that Th1 (CD4 + IFN-γ +) cells were significantly decreased in the spleen in plateau hypoxia (Figure 7 B), and significantly increased after drug administration; plateau hypoxia did not have a significant effect on Th2 (CD4 + IL-4 +) cells (Figure 7 D), which might be related to the low expression of IL-4.

We have investigated intracellular T-helper type 1 (Th1) cytokines in the spleens of gut wall-transplanted scid mice with IBD. Increased fractions of interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and IL-2-positive CD4 + T cells were found in the spleens of diseased mice compared with control mice.

Mar 17, 2025 · This panel dissects the memory T cell compartment via CD62L and CD44 expression after mitogen stimulation. To profile T helper (Th) cell distribution after mitogen stimulation, established Th1 markers IFNγ, TNF, and IL-2; Th2 markers IL-4/5; and the Th17 marker, IL-17, are included.

Our findings suggest that Listeria exploit the defective Th1 environment of the spleen in the initial phase and afterwards overcome the host defense mechanism of the liver.

Apr 29, 2024 · Functional cytokines shape both innate and adaptive immune responses in the host after infection or immunization. Deep immunophenotyping of the key functional cytokine signatures associated with T cells in murine lymphoid tissue, especially in …

Homing studies demonstrated that transferred Th1 cells express CXCR4, which was associated with accumulation within bone marrow and spleen. Allogeneic Th1 cells were activated by radiation-resistant host bone marrow cells and induced bone marrow failure through an IFNγ-dependent mechanism.

This study demonstrate that AS-IV treatment can ameliorate abnormalities in inflammatory factors within the Th1/Th2 cell pathway in the spleen of mice induced by hypobaric hypoxia, but its regulatory effects on transcription factors are limited.

Mar 13, 2025 · In summary, simulating hypoxia at an altitude of 7000 m for 5 days can establish a stable hypobaric hypoxic immune injury model, and AS-IV can effectively alleviate hypobaric hypoxic immune injury. Keywords: Astragaloside IV; Th1/Th2; hypobaric hypoxia; immune imbalance; spleen.

Jul 24, 2020 · Our findings indicate that superfluous fluoride intake damages the balance of Th1/Th2 cells by changing the levels of T-bet and GATA3 in the spleen, and further changes the expression of Th1/Th2 cell-related cytokines in the spleen microenvironment, eventually leading to …

The data suggested that the abnormal expression of Th1/Th2 chemokine receptors may participate in splenic immune disorder in patients with ITP. Using corresponding inhibitors may inhibit Th1-dominant expression and mitigate the progress of the disease.