The Th1 life cycle: molecular control of IFN-γ to IL-10 switching
May 2, 2011 · In this review, the molecular pathways that regulate IFN-γ versus IL-10 expression in Th1 cells are examined, with focus on the role of complement regulator and T cell co …
Interferon gamma - Wikipedia
The primary cells that secrete type II IFN are CD4 + T helper 1 (Th1) cells, natural killer (NK) cells, and CD8 + cytotoxic T cells. It can also be secreted by antigen presenting cells such as …
Biologic functions of the IFN‐γ receptors - PMC
Th1 cells are primarily defined by their ability to secrete IFN‐γ, IL‐2, and tumor necrosis factor (TNF)‐β, and are clinically associated with an ability to orchestrate cell‐mediated immune …
Th1 (IL-2, interferon-gamma (IFN-γ)) and Th2 (IL-10, IL-4) cytokine ...
Th1 cells produce IL-2, IFN-γ and tumour necrosis factor-beta (TNF-β), and promote both macrophage activation resulting in DTH, and production of complement-fixing and -opsonizing …
Role of IFN-γ in Th1 Differentiation: IFN-γ Regulates IL-18Rα ...
Jun 15, 2002 · As IFN-γ has been reported to be capable of inducing Th1 differentiation in the absence of IL-12, we extended our studies to examine the role of IFN-γ in the regulation of IL …
Pathophysiology of Th1 and Th2 Responses in Humans
Jan 1, 1997 · Th1 cells secrete interleukin (IL)-2, tumor necrosis factor (TNF)β, and interferon (IFN)γ are the principal effectors of cell-mediated immunity against intracellular microbes and …
A direct role for IFN-gamma in regulation of Th1 cell development
Aug 15, 1996 · With optimal TCR stimulation and costimulation, endogenous IFN-gamma, without IL-12, was sufficient to elicit Th1 cells via an autocrine mechanism, whereas with suboptimal …
Induction of interferon-gamma production in Th1 CD4+ T cells: …
IFN-gamma produced by CD4+ T helper 1 (Th1) cells promotes protection against intracellular pathogens. Antigen activation of Th1 cells is an important mode of IFN-gamma induction, but …
IL-4-mediated inhibition of IFN-gamma production by CD4+ T …
During the commitment phase of naive CD4+ T cells, IL-4 inhibits Th1 cell differentiation and induces a reversion of developing Th1 cells to the Th2 lineage. In contrast, for effector Th1 …
IFN-γ Production by Th1 Cells Generated from Naive CD4
Jan 1, 2001 · In this study, Th1 cells were generated from naive CD4 + T cells stimulated through the β 2 AR during the first 48 h of T cell activation, a time during which a number of cellular …
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