Nov 1, 2023 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and …

Th1- and Th2-like responses can help CD8 memory cell development. To examine the effectiveness of Th1 versus Th2 help in the development of memory CD8 T-cell responses, we …

Here we show that CD8 (+) T cells, through the interaction with DCs, can induce the rapid development of human monocytes into Tip-DCs that express high levels of TNF-α and iNOS.

Mar 15, 2011 · In this study, we demonstrate that CD8 + T cells can induce the rapid development of human monocytes into Tip-DCs that are capable of further driving Th1 responses by priming …

As CD8 T cells underwent a second phase of stable interactions with DCs, helper CD4 T cells halted briefly before moving on to another DC, whereas regulatory T cells did not stop. ... O. …

In this article we discuss how inflammatory cytokines and IL-2 bias the initial response towards short-lived effector generation and also highlight the potential counterbalancing role of IL-21.

May 23, 2013 · Th1 CD4 T cells preferentially homed to and accumulated within intracranial tumours compared with Th2 CD4 T cells. Moreover, tumour-antigen specific Th1 CD4 T cells …

Mar 12, 2025 · This expansion ensures an effective response, allowing Th1 cells to persist in infected tissues. CD8+ T cells, primarily cytotoxic, can also produce Th1 cytokines when …

Mar 18, 2025 · CD8 + T cell subsets interact with macrophages through different ligand-receptor networks, including the CCL-CCR signaling pathway and costimulatory molecules. ... Th1/Th2 …

6 days ago · cDC1s are superior to cDC2-based cancer vaccination in generation of CD4 + Th1 and CD8 + T cell effector responses. The blood is the most feasible source of autologous …