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Past, present, and future perspectives of transcription factor EB …
Jun 23, 2022 · Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors, is an established central regulator of the...
From the regulatory mechanism of TFEB to its therapeutic ... - Nature
Feb 16, 2024 · Transcription factor EB (TFEB), known as a major transcriptional regulator of the autophagy-lysosomal pathway, regulates target gene expression by binding to coordinated …
METTL3 and ALKBH5 oppositely regulate m6A modification of …
Mechanistically, METTL3 methylates TFEB, a master regulator of lysosomal biogenesis and autophagy genes, at two m 6 A residues in the 3'-UTR, which promotes the association of the …
- Author: Huiwen Song, Xing Feng, Heng Zhang, Yunmei Luo, Juan Huang, Meihua Lin, Junfei Jin, Xue Ding, Shujin...
- Publish Year: 2019
THOC4 regulates energy homeostasis by stabilizing TFEB mRNA …
Mar 22, 2021 · In this study, we identified the mRNA-binding protein THOC4 as a novel regulator of TFEB. In mammalian cells, siRNA-mediated knockdown of THOC4 decreased the level of …
- Author: Toshiharu Fujita, Sayaka Kubo, Tatsuya Shioda, Ayaka Tokumura, Satoshi Minami, Megumi Tsuchiya, Yosh...
- Publish Year: 2021
METTL3 and ALKBH5 oppositely regulate m6A modification of …
Mar 17, 2019 · Mechanistically, METTL3 methylates TFEB, a master regulator of lysosomal biogenesis and autophagy genes, at two m 6 A residues in the 3Ęą-UTR, which promotes the …
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Molecular Genetics and Cellular Characteristics of TFE3 …
Wild-type TFEB mRNA produces a 476-AA protein similar to TFE3 with a 10-AA strong transcription activation domain (AD 156AA-165AA), a 54-AA basic region and helix-loop-helix domain (bHLH 235AA-288AA) containing a putative …
TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator
In this review, we provide updated insights into novel post-translational modifications that regulate TFEB activity and give an overview of TFEB beyond its widely known role in autophagy and …
The cGAS-STING pathway activates transcription factor …
Feb 11, 2025 · STING activation enhanced lysosome biogenesis through inducing the nuclear translocation of transcription factor EB (TFEB) as well as its paralogs transcription factor E3 (TFE3) and microphthalmia-associated transcription …
In this review, we describe how the intracellular environment characteristic of different dis-eases alters the post-translational modification profile of TFEB, enabling cellular adaptation to a …
