Nov 26, 2024 · We identify a distinct nuclear interactome of TFEB, with ubiquitin-specific protease 7 (USP7) emerging as a key post-translational modulator of TFEB. Genetic depletion and inhibition of USP7 reveal its critical role in preserving TFEB stability within both nuclear and cytoplasmic compartments.

In this study, we aimed to investigate the importance of TFEB acetylation in control of TFEB transcriptional activity, and implications of such a mechanism in regulation of lysosomal function, autophagy and therapeutic effects of HDACIs in cancer.

Mar 22, 2021 · To prove whether TFEB is sequestered in the cytoplasmic β-catenin destruction complex, we examined the interaction between TFEB and Axin. Immunoprecipitation (IP) assays revealed that TFEB...

Polyclonal Antibody for studying TFEB. Validated for IP, WB. Highly specific and rigorously validated in-house, TFEB Antibody (CST #4240) is ready to ship.

Aug 16, 2024 · Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localized to the cytoplasm.

Jan 23, 2024 · TFEB is a master regulator of autophagy, lysosome biogenesis, mitochondrial metabolism, and immunity that works primarily through transcription controlled by cytosol-to-nuclear translocation. Emerging data indicate additional regulatory interactions at the surface of organelles such as lysosomes.

Mar 16, 2023 · TFEB is a transcription factor known to be phosphorylated by mTORC1 at multiple sites under replete conditions; this leads to its inactivation and hence suppresses lysosome biogenesis and...

May 1, 2020 · In this review, we present an overview of the current data on TFEB and its implication in kidney disease. The transcription factor EB regulates the expression of CLEAR motif-containing target...

Choose from 1 of 23 TFEB antibodies, which have been validated in experiments with 143 publications and 66 images featured in our data gallery. Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications....