TFAM binds mitochondrial promoter DNA to aid transcription of the mitochondrial genome. Studies in mice have demonstrated that this gene product is required to regulate the …

May 23, 2024 · We discovered that mitochondrial transcription factor A (TFAM)—a protein that binds mitochondrial DNA (mtDNA)—helps to eliminate leaked mtDNA by interacting with the …

Dec 25, 2024 · TFAM (Transcription Factor A, Mitochondrial) is a Protein Coding gene. Diseases associated with TFAM include Mitochondrial Dna Depletion Syndrome 15 and Mitochondrial …

Oct 18, 2021 · Mitochondrial transcriptional factor A (TFAM) acts as a key regulatory to control mitochondrial DNA (mtDNA); the impact of TFAM and mtDNA in modulating carcinogenesis is …

The mitochondrial transcription factor A, or TFAM, is a mitochondrial DNA (mtDNA) binding protein essential for genome maintenance. TFAM functions in determining the abundance of …

The mitochondrial transcription factor A, or TFAM, is a mitochondrial DNA (mtDNA)-binding protein essential for genome maintenance. TFAM functions in determining the abundance of …

TFAM is essential for transcription, replication and packaging of mtDNA into nucleoids. Tfam knockout mice display embryonic lethality secondary to severe mtDNA depletion. In this report, …

Transcription Factor A Mitochondrial (TFAM) was first purified 35 years ago as an activator of mitochondrial transcription. Because of its critical contributions to mitochondrial DNA …

TFAM is a core mitochondrial transcription factor, responsible for recruiting mitochondrial RNA polymerase and transcription factor T2BM to activate transcription.

Oct 30, 2011 · Tfam (transcription factor A, mitochondrial), a DNA-binding protein with tandem high-mobility group (HMG)-box domains, has a central role in the expression, maintenance …