Jul 26, 2022 · GDGT contains two 40-carbon lipid chains (biphytanyl chains) that span both leaflets of the membrane, providing enhanced stability to extreme conditions. How these specialized lipids are formed...

Jun 1, 2009 · This microreview describes the particular features of tetraether-type archaeal lipids and their potential applications in biotechnology. Natural and synthetic tetraether lipid structures as well as their applications in drug/gene delivery, …

Mar 1, 2010 · Bipolar tetraether lipids (BTL) are abundant in archaea and can be chemically synthesized. The structures of BTL are distinctly different from the lipids found in bacteria and eukaryotes. In aqueous solution, BTL can form extraordinarily stable liposomes with different sizes, lamellarities and membrane packing densities.

Basic structures of Archaeal ether lipids. In addition, a group of tetraethers with a strikingly different molecular architecture have been discovered as core lipids of the Archaea, especially in the thermophilic Crenarchaea.

Diether and tetraether lipids are fundamental components of the archaeal cell membrane. Archaea adjust the degree of tetraether lipid cyclization in order to maintain functional membranes and cellular homeostasis when confronted with pH and/or thermal stress.

Dec 18, 2019 · Here, we demonstrate that liposomes made of synthetic bipolar tetraether lipids can also undergo membrane fusion, which is commonly accompanied by content leakage of liposomes when using typical...

Tetraether membranes, termed glycerol dibiphytanyl glycerol tetraethers (GDGTs), are generated by tetraether synthase (Tes) by joining the tails of two bilayer lipids known as archaeol. GDGTs are often further specialized through the addition of …

Feb 11, 2022 · Glycerol dibiphytanyl glycerol tetraethers (GDGT) are some of the most unusual membrane lipids identified in nature. GDGT lipids are characterized by multiple branching, ether linkages, cycloalkane rings, and often span the entire length of the membranes.

Aug 7, 2024 · Archaeal bipolar tetraether lipids (BTLs) are among the most unusual lipids occurring in nature because of their presumed ability to span the entire membrane to form a monolayer structure.

GDGT contains two 40-carbon lipid chains (biphytanyl chains) that span both leaflets of the membrane, providing enhanced stability to extreme conditions. How these specialized lipids are formed has puzzled scientists for decades.