Collectively, our findings identify a novel function of TERC that regulates the PI3K-AKT pathway via positive feedback to elevate cell proliferation independent of telomerase activity and provide a potential strategy to promote CD4 + T cells expansion that is responsible for enhancing adaptive immune reactions to defend against pathogens and tum...

Apr 22, 2022 · Here, we reported positive feedback regulation between TERC and the PI3K-AKT pathway that controlled cell proliferation independent of telomerase activity in human fibroblasts. Mechanistically, we revealed that TERC activated the transcription of target genes from the PI3K-AKT pathway, such as PDPK1, by targeting their promoters.

Feb 1, 2021 · More recent studies confirm the interaction of the telomerase with various intracellular signaling pathways including PI3K/AKT/mTOR, NF-κB and Wnt/β-catenin which mainly participating in inflammation, epithelial to mesenchymal transition (EMT) and tumor cell invasion and metastasis.

Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase complex plays a key role in cancer formation by telomere dependent or independent mechanisms.

These data indicate that STAT5 is one of the transcription factors that regulate TERT expression in IL-2-stimulated ATL cells. TERT also interacts directly with the PI3K/Akt/HSP90/mTORC1 pathway in an IL-2-dependent fashion.

Mar 22, 2022 · Collectively, our findings identify a novel function of TERC that regulates the PI3K-AKT pathway via positive feedback to elevate cell proliferation independent of telomerase activity and provide...

Aug 30, 2023 · In this study, we expressed TERT and/or active BRAF (BRAF V600E) specifically in mouse thyroid epithelium. While BRAF V600E alone induced papillary thyroid cancer (PTC), coexpression of BRAF V600E and TERT resulted in poorly …

A novel function of TERC is identified that regulates the PI3K-AKT pathway via positive feedback to elevate cell proliferation independent of telomerase activity and provide a potential strategy to promote CD4+ T cells expansion that is responsible for enhancing adaptive immune reactions to defend against pathogens and tumor cells.

1 day ago · TP53 (48%), TERT promoter (36.5%), and BRAF (23%) are most frequently mutated in PDTC and ATC. ... The activation of IRS2-PI3K/AKT signaling potentiates the self-renewal of breast cancer stem ...

Jul 7, 2019 · PI3K/AKT/mTOR pathway gene mutation is tightly associated with anaplastic oligodendroglioma orthotopic xenograft formation. We identified 15 mutations in YMG6R3Tsc1 xenografts (Fig. 2I, Supplementary Table 2). Among them, 8 mutations, including IDH1 R132H, TERT promoter, PIK3CA E542K, were retained