Oct 17, 2019 · Human tissue T cells are largely memory subsets, comprising tissue-resident (TRM) and non-resident (TEM, TCM) populations; TRM predominate in mucosal sites, while TEM are found in spleen,...

We identify a core transcriptional profile within the CD69 + subset of memory CD4 + and CD8 + T cells in lung and spleen that is distinct from that of CD69 − TEM cells in tissues and circulation, and defines human TRM based on homology to the transcriptional profile of mouse CD8 + TRM.

Jun 14, 2021 · We analyzed the TCR repertoire of the major memory CD4+ and CD8+T cell subsets (TEM, TCM, TEMRA, and TRM) isolated from blood and/or lymphoid organs (spleen, lymph nodes, bone marrow) and lungs of nine organ donors, and blood of three living individuals spanning five decades of life.

Classifications of memory CD8 T cells into, Tem, Tcm, Trm, and Tpm subsets informs our understanding of immuno-surveillance provided by CD8 T cells of discrete functionality, but it does not capture the complete diversity within the memory CD8 T cell pool.

Trm cells primarily exist as residents of tissues without recirculating back to blood and function as a first line of defense against reinfection (Masopust et al. 2006; Schenkel and Masopust 2014; Mueller and Mackay 2016; Szabo et al. 2019). In many tissues, Trm …

In this review, we categorize different tissues in the body based on patterns of memory T-cell migration and tissue residency. This review also describes the rules for TRM generation and the properties that distinguish them from circulating TEM and TCM cells.

Trm, Tem, and Tcm cells are derived from the same naïve T cell clone upon activation in SLOs. CD8⁺ Trm cell precursors migrate into peripheral tissues as well as SLOs where they differentiate...

Oct 8, 2019 · These precursor cells ultimately develop into several subsets of memory T cells, including central memory T (TCM) cells, effector memory T (TEM) cells, and tissue resident memory T (TRM) cells.

Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tis-sues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance. Because Trm cells are not present within peripheral blood, they

Memory T cells are typically parsed into discreet subsets based on phenotypic definitions that connote distinct roles in immunity.