Hexokinase 2 (HK2) is widely distributed in various tissues, particularly showing significantly elevated expression levels in tumor tissues. As the initial rate-limiting enzyme in the glycolysis process, HK2 is believed to directly participate in the metabolic reprogramming of tumor cells.

We show that hexokinase 2 (HK2) a metabolic enzyme fuelling cancer cell growth, is a transcriptional target of AHR as well as a modulator of its activity. Expression of HK2 is positively regulated by AHR upon exposure to agonists both in human cells and in mice lung tissues.

Triethylammonium acetate is a volatile salt, which is often used as an ion-pairing reagent in high-performance liquid chromatography separations of oligonucleotides. [1][2][3][4] Since unadjusted triethylammonium acetate salt solutions contain neither a conjugate acid nor a conjugate base, they are not buffers.

Hexokinase 2 (HK2), which catalyzes the first committed step in glucose metabolism, is induced in cancer cells. HK2’s role in tumorigenesis has been attributed to its glucose kinase activity. Here, we describe a kinase independent HK2 activity, which contributes to metastasis.

Sep 25, 2017 · Chromatin immunoprecipitation (ChIP) assay shows that YAP/TEAD (TEA domain family member) and p65 proteins synergistically regulate the transcription of hexokinase 2 (HK2), a speed-limiting...

Aug 12, 2013 · Targeting HK2, which is highly expressed in glycolytic cancer cells and not in normal cells, could selectively target cancer cells. Using genetic approaches, we showed that HK2 is required for tumor initiation and maintenance, and its deletion is therapeutic for cancer.

Oct 31, 2013 · In cancer cells, HK2 is a major propelling wheel in glucose metabolism to support accelerated ribonucleotide synthesis and glutamine utilization in the TCA cycle, and to fulfill anabolic demands. HK2 ablation decelerates these pathways resulting in …

Aug 17, 2018 · Hexokinase 2 (HK2) is one of the most highly upregulated metabolic enzymes in both cancer and activated T cells. HK2 is required for the development and/or growth of cancer in several cancer models, but the necessity of HK2 in T cells is not fully understood.

Some compounds have also shown potential in inhibiting HK2-mediated enhancement of glycolysis in tumor cells. This article summarizes the role of HK2 in regulating tum r metabolic reprogramming and presents advancements in anticancer research of cert in natural HK2 inhibitors. In conclusion, HK2

Hexokinase II, also known as Hexokinase B and HK2, is an enzyme which in humans is encoded by the HK2 gene on chromosome 2. [5][6] Hexokinases phosphorylate glucose to produce glucose 6-phosphate, the first step in most glucose metabolism pathways.