T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene. [5] [6] [7]

Mar 30, 2025 · TCL1A (TCL1 Family AKT Coactivator A) is a Protein Coding gene. Diseases associated with TCL1A include Leukemia and Precursor T-Cell Acute Lymphoblastic …

Apr 12, 2023 · A genome-wide association study revealed that a common inherited polymorphism in the TCL1A promoter was associated with a slower expansion rate in clonal haematopoiesis …

TCL1A acts as a coactivator of the serine threonine kinase Akt and through other interactions favoring cell survival, growth, and proliferation. It has also been identified as interacting with …

TCL1A expression delineates biological and clinical variability in B-cell lymphoma. Tcl1A unique set of molecules, Tcl1 and galectin-1, defines distinct B cell receptor signaling cascades, …

Jun 1, 2021 · TCL1A has first been identified as an oncogene, overexpression of which is associated to the development of T and B cell cancer. TCL1A acts as a coactivator of the …

Mar 23, 2023 · Downregulated CDC20 in CLL cells resembles the aneuploidy phenotype and is associated with more aggressive disease and cellular features. Proposed integrative model of …

Oct 29, 2021 · Understanding how TCL1A is deregulated and how this can lead to tumor initiation and sustenance can help in future approaches to interfere in its oncogenic actions.

Aug 13, 2018 · Almost 30 years ago, Carlo Croce's group discovered the T-Cell Leukemia/Lymphoma 1A oncogene (TCL1A or TCL1). TCL1 protein is normally expressed in …

Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t (14;14) (q11;q32); translocation t (7;14) (q35;q32); inversion inv (14) (q11;q32) …