“T cell factor 1” (HUGO gene name TCF7 [van de Wetering et al. 1991]) and “lymphoid enhancer factor 1” (HUGO gene name LEF1 [Travis et al. 1991; Waterman et al. 1991]) were discovered …

Transcription factor 7 (TCF7) plays an essential role in Wnt signaling by interacting with β-catenin. Emerging evidence demonstrates that overexpression of TCF7 promotes progression or …

Mar 3, 2023 · Here, we demonstrate that transcriptional repression exerted by Wnt/TCF7L1 promotes PE differentiation of mESCs and in preimplantation inner cell mass.

T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) proteins (TCFs) from the High Mobility Group (HMG) box family act as the main downstream effectors of the Wnt signaling pathway. …

Nov 13, 2018 · Western blots for detection of TCF7, LEF1, TCF7L1, TCF7L2 and β‐catenin (B′) proteins in wild‐type (WT) and knockout (K.O.) cells. Uncropped version of the same Western …

Mar 20, 2020 · Our results show that the vital necessity for TCF7L2 in healthy intestinal cells is broadly lost in the course of colorectal carcinogenesis. Even though TCF7L2-negative cells …

Aug 20, 2015 · TCF7 interacts with multiple proteins and target genes (e.g. CD3E, β-catenin, TCF7L2, LEF-1, IL-17, IL-4, or Eomes) and is involved in several signal pathways (e.g. Wnt, …

Jan 1, 2015 · TCF7, a WNT signaling-related gene, has been implicated as a critical factor in bone metastasis, and here we show that TCF7 is a direct target of miR-34a. In samples of …

4 days ago · In TCF7L2 mutant livers, no changes in the expression of related Wnt transcription factors Tcf7 (Fig. 3H) and Lef1 (Fig. 3I) were observed. TCF7L2 inactivation eliminates zone 3 …

Nov 27, 2024 · Wnt/β-catenin/transcription factor (TCF) transcriptional activity plays an integral role in colorectal cancer (CRC) carcinogenesis. However, to date, no drugs targeting this …