Tbx20 is a transcription factor that is essential for proper heart development in a growing fetus. Any mutations in this gene can result in various forms of congenital heart disease. One of the more serious examples is the presence of a septal defect.

Mar 30, 2025 · TBX20 (T-Box Transcription Factor 20) is a Protein Coding gene. Diseases associated with TBX20 include Atrial Septal Defect 4 and Hypoplastic Left Heart Syndrome. Among its related pathways are Nervous system development and Cardiogenesis.

Sep 14, 2022 · TBX20 consolidates MGT cardiac reprogramming factors to activate cardiac enhancers to promote cardiac cell fate conversion. Human induced cardiomyocytes generated with TBX20 showed enhanced cardiac function in contractility and mitochondrial respiration.

Tbx20 is a member of the Tbx1 subfamily of T-box-containing genes and is known to play a variety of fundamental roles in cardiovascular development and homeostasis as well as cardiac remodeling in response to pathophysiological stresses.

Here, we report nonsense (Q195X) and missense (I152M) germline mutations within the T-box DNA-binding domain of human TBX20 that were associated with a family history of CHD and a complex spectrum of developmental anomalies, including defects in septation, chamber growth, and valvulogenesis.

Feb 8, 2025 · Tbx20 regulated PPAR-gamma expression and protected the vascular endothelial cells from oxidized low-density lipoprotein -induced injury. Tbx20 functions as an important regulator of estrogen-mediated cardiomyocyte protection during oxidative stress.

Jan 29, 2024 · Clinical resource with information about TBX20, Atrial septal defect 4, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Mar 1, 2023 · The Tbx20 has been linked to a variety of heart diseases, including atrial septal defect (ASD), ventricular septal defect (VSD), tetralogy of Fallot (TOF), dilated cardiomyopathy (DCM), and so on. Tbx20 also plays a major part in promoting cardiomyocyte proliferation and …

Aug 30, 2023 · These findings strongly indicate that TBX20 is a new AF-predisposing gene, shedding light on the mechanism underlying AF and suggesting clinical significance for the individually tailored treatment of AF.

Jan 28, 2021 · Tbx20 is a member of the Tbx1 subfamily of T-box-containing genes and is known to play a variety of fundamental roles in cardiovascular development and homeostasis as well as cardiac remodeling in response to pathophysiological stresses.