Targeting TBK1 to overcome resistance to cancer immunotherapy
Jan 12, 2023 · Using a suite of genetic and pharmacological tools across multiple experimental model systems, we confirm a role for TBK1 as an immune-evasion gene. Targeting TBK1 …
PTK2B promotes TBK1 and STING oligomerization and enhances …
Nov 21, 2023 · TANK-binding kinase 1 (TBK1) is a key kinase in regulating antiviral innate immune responses. While the oligomerization of TBK1 is critical for its full activation, the …
Nature | 李平卫团队揭示STING招募和激活TBK1的分子机制 - 知乎
更进一步的IFN-β 荧光素酶报告分析证实这些突变影响干扰素的表达。 Westernblot和免疫共沉淀也证实这些突变影响cGAS-STING通路的激活。 不同物种的STING氨基酸序列分析发现结 …
A Novel Transcript Isoform of TBK1 Negatively Regulates Type I IFN ...
Sep 29, 2020 · TANK-binding kinase 1 (TBK1), an IKK-related serine/threonine kinase, is pivotal for the induction of antiviral type I interferon (IFN) by TLR and RLR signaling pathways.
TBK1 recruitment to STING activates both IRF3 and NF-κB that ... - PubMed
Apr 6, 2021 · We also generated STING mice with mutations that disrupt the recruitment of TANK-binding kinase 1 (TBK1), which is important for both IRF3 and NF-κB activation but not …
Casein Kinase II Controls TBK1/IRF3 Activation in IFN Response …
May 1, 2015 · In this study, we report that protein kinase CK2 serves as a key component controlling TBK1 and IRF3 activation in IFN-inducing TLR, RIG-I–like receptors, and …
STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic …
Mar 6, 2012 · As part of the innate immune response, various pattern recognition receptors, such as Toll-like receptor 3 (TLR3) and TLR4, activate the kinase TBK1, which phosphorylates the …
TBK1, a central kinase in innate immune sensing of nucleic
Jul 10, 2020 · TANK-binding kinase 1 (TBK1), along with its close analogue I-kappa-B kinase epsilon, is a central kinase in innate adaptor complexes linking activation of PRRs to …
Frontiers | TBK1 is paradoxical in tumor development: a focus on …
Aug 4, 2024 · Regulation of IFN-I expression is a significant mechanism underlying TBK1’s role in tumor development. IFN-I exerts a dual role in tumor immunity, both inhibiting tumor growth …
TBKBP1 and TBK1 form a growth factor signalling axis mediating ...
Dec 2, 2019 · TANK-binding kinase 1 (TBK1) responds to microbial stimuli and mediates the induction of type I interferon (IFN). Here, we show that TBK1 is also a central mediator of …