The designation 'primary tauopathy' is assigned to disorders where the predominant feature is the deposition of tau protein. Alternatively, diseases exhibiting tau pathologies attributed to different and varied underlying causes are termed 'secondary tauopathies'.

Tauopathies are often classified based on the primary tau protein isoform deposited in the brain, including 3R tauopathies, exemplified by Pick’s disease (PiD); 4R tauopathies, such as progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), argyrophilic grain disease (AGD), and globular glial tauopathy (GGT); and combined 3R/4R ...

Primary age-related tauopathy (PART) describes pathology that consists of AD-like NFTs and few or no Aβ plaques . In contrast to AD, NFTs in PART are mainly circumscribed in temporal lobes, basal forebrain, brainstem and olfactory bulb . Whether PART is a distinct pathology or represent early stages of AD is under discussion .

Human postmortem studies have elucidated broad patterns of tauopathy, with tendencies for those patterns to differ as a function of disease phenotype. However, there is extensive overlap, not only between genuine neurodegenerative diseases, but also between aging and disease.

Keywords: Alzheimer’s disease; metabolic syndrome; neurodegeneration; tau; tauopathy; traumatic brain injury.

Aug 1, 2017 · Tauopathy is an umbrella term that subsumes many different entities, all characterized by the abnormal deposition of tau in the brain. 1-3 Many entities subsumed under the umbrella term tauopathy are diseases that can have varying clinical presentations, some of which can overlap between diseases, resulting in a complex web of clinical ...

Tauopathy is a term that encompasses both the loss-of-function effects on the microtubules and the gain-of-function effects of the toxic tau species. There are currently no disease-modifying therapies for the treatment of tauopathies. Pathophysiology [edit | edit source]

Emerging entities and pathologies include globular glial tauopathies, primary age-related tauopathy, which includes neurofibrillary tangle dementia, chronic traumatic encephalopathy (CTE), and aging-related tau astrogliopathy.

Tauopathy refers to a group of neurodegenerative disorders characterized by abnormal neuronal and/or glial inclusions of the protein tau, forming hyperphosphorylated insoluble aggregates. AI generated definition based on: Handbook of Clinical Neurology , 2023

Apr 25, 2017 · A current hypothesis posits that primary age-related tauopathy, while not a brain injury in the classical sense, is a result of the mild ‘wear and tear’ on the brain that inevitably accumulates over a lifetime .