Jun 18, 2014 · Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique conformations ("strains") in vivo that link structure to patterns of pathology. …

The tau proteins (abbreviated from tubulin associated unit [5]) form a group of six highly soluble protein isoforms produced by alternative splicing from the gene MAPT (microtubule-associated protein tau).

In sporadic diseases, assemblies of tau form in a stochastic manner in certain brain regions, from where they appear to spread in a deterministic way, giving rise to disease symptoms. Over the past decade, multiple lines of evidence have shown that assembled tau behaves like a prion.

Tau is a microtubule-associated protein that functions in regulating cytoskeleton dynamics, especially in neurons. Misfolded and aggregated forms of tau produce pathological structures in a number of neurodegenerative diseases, including Alzheimer’s disease (AD) …

Prion protein (PrP c) 2 is a normal cellular protein that can be converted to a disease-causing conformation (PrP Sc) through interaction with a pathogenic prion protein “seed.”

We review, here, the state of the art of the research on tau prion-like propagation and we highlight some key challenges to understanding the detailed mechanisms of cell to cell propagation.

We have now isolated 18 putative tau prion strains derived from recombinant, mouse, or human sources. We have studied them extensively in vivo, and find that they can account for diverse and predictable patterns of neuropathology.

Jul 7, 2014 · Prion protein (PrP c) 2 is a normal cellular protein that can be converted to a disease-causing conformation (PrP Sc) through interaction with a pathogenic prion protein “seed.”

Feb 25, 2020 · We review, here, the state of the art of the research on tau prion-like propagation and we highlight some key challenges to understanding the detailed mechanisms of cell to cell propagation. What is the evidence that tau pathology spreads through prion-like propagation?

Jun 18, 2014 · Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for …