Inhaled ciprofloxacin-loaded poly (2-ethyl-2-oxazoline) …
Dec 23, 2021 · The in vitro aerosolization study carried out using a Twin Stage Impinger (TSI) at 60 L/min air flow showed the fine particle fraction (FPF) between 34.4% and 40.8%. The FPF was increased with increased drug loading.
Comparative Assessment of In Vitro and In Silico Methods for ...
The differences between TSI and NGI results are probably caused by the fact that TSI considers particles smaller than 6.4 µm to be respirable, whereas the cut-off aerodynamic diameter for NGI FPF values is 5 µm.
Dry powder inhalers: The influence of device resistance and …
Dec 1, 1998 · A TSI operated at 60 l min −1 for 10 s was employed to detect the FPF (<6.4 μm) from the firing of a single dose from each inhaler. Lactose was analysed by HPLC using an amino column together with a refractive index detector (Erma, Japan).
Determination methods for in vitro deposition of metered dose …
Oct 29, 2016 · Objective To analyze and compare fine particle fraction (FPF) and particle size distribution (PSD) measured by twin-stage impactor (TSI), Andersen cascade impactor (ACI) and next generation...
Role of Agglomeration in the Dispersion of Salmeterol Xinafoate …
Aug 1, 2008 · The fine particle fraction (FPF) was defined as the amount of SX deposited in the lower stage (stage two) of the TSI as a percentage of the total recovered dose (defined as drug content collected from all components of TSI and inhaler).
Inhaled ciprofloxacin-loaded poly (2-ethyl-2-oxazoline ... - PLOS
Dec 23, 2021 · The in vitro aerosolization study carried out using a Twin Stage Impinger (TSI) at 60 L/min air flow showed the fine particle fraction (FPF) between 34.4% and 40.8%. The FPF was increased with increased drug loading.
In vitro drug deposition results for spray freeze-dried formulations …
This study showed that the aerosolization of microparticles containing HBCD 0.05% had the lowest ED and FPF, 88.53% and 23.79%, respectively, while the FPF increased to 2-times for A c c e p t e...
Inhaled ciprofloxacin-loaded poly (2-ethyl-2-oxazoline ... - PubMed
Dec 23, 2021 · The in vitro aerosolization study carried out using a Twin Stage Impinger (TSI) at 60 L/min air flow showed the fine particle fraction (FPF) between 34.4% and 40.8%. The FPF was increased with increased drug loading.
Comparison between the respirable and non-respirable dose …
The differences between TSI and NGI results are probably caused by the fact that TSI considers particles smaller than 6.4 µm to be respirable, whereas the cut-off aerodynamic diameter for NGI FPF...
Comparative Assessment of In Vitro and In Silico Methods for ...
Comparative analysis of the in vitro results revealed that TSI and FSI testing indicated higher FPF values than NGI results ( Figure 15 ). The differences between TSI and NGI results are probably caused by the fact that TSI considers particles smaller than 6.4 µm to be respirable, whereas the cut-off aerodynamic diameter for NGI FPF values is ...