Dec 1, 2013 · Overexpression of S100A4 led to a reduced activation of NFAT by TSH. Using S100A4 E33Q, D63N, F72Q and Y75K mutants we found that the effects of S100A4 expression on Ca 2 + signaling are mediated by protein interaction.

Screening for interference in thyroid hormone (T4 and T3) and/or thyrotropin (TSH) laboratory assays should be considered in any patient with apparently anomalous or discordant TFTs.

Oct 23, 2023 · We develop pathway-specific genetic risk scores for TSH levels and use these in phenome-wide association studies to identify potential consequences of pathway perturbation.

Feb 24, 2025 · In this paper, Gαs-cAMP-PKA and Gαq/11-PLC-Ca 2+, two signal transduction pathways that are intimately associated with TSH function, were successfully used to construct double transfected HEK293-TSHR stable lines containing CRE or NFAT response elements (RE) tagged to a modified form of the luciferase reporter, and two RGAs that are highly ...

Jan 2, 2025 · Secretion of the thyroid hormones T4 (thyroxine) and T3 (triiodothyronine) is regulated by pituitary thyroid-stimulating hormone (TSH) (figure 1 and figure 2). TSH secretion, in turn, is controlled through negative feedback by thyroid hormones (see "Thyroid hormone synthesis and physiology").

Seth et al. demonstrate that AP-1–independent NFAT gene expression, typically associated with hyporesponsive T cells, is required for Tfh cell maintenance and is a therapeutic target in murine lupus. Coordinated gene expression programs enable development and function of T cell subsets.

Jun 1, 2005 · Experimental evidence indicates that, during T-cell development, calcium–calcineurin–NFAT signalling is a key regulator of positive selection. NFAT2 and NFAT4 might also control thymocyte...

The NFAT family of transcription factors plays an established role in T cell activation. Rao and colleagues show that NFAT also controls the program of T cell exhaustion by regulating the expression of key inhibitory receptors and signaling molecules that dampen TCR signaling.

Mar 1, 2010 · Nach einer totalen Thyreoidektomie kommt es unter dem Einfluss von TSH (Thyreoidea-stimulierendes Hormon) zu einer kompensatorischen Volumenzunahme des bis dahin asymptomatischen ektopen Gewebes.

Jun 26, 2020 · By virtue of its structural property, the TSH receptor (TSHR) has a unique ability to engage different G proteins making it highly amenable to selective signaling. In this study, we describe the identification and characterization of a novel small molecule agonist to the TSHR which induces primary engagement with G αq/11.