Tumor suppressor TSC1 is critical for T-cell anergy - PNAS
We report here that tuberous sclerosis (TSC)1 is critical for T-cell anergy. Deficiency of TSC1 resulted in enhanced T-cell proliferation and cytokine production in the absence of cluster of …
mTORC1 impedes osteoclast differentiation via calcineurin and …
Apr 5, 2018 · Gain-of-function genetic models by TSC1 deletion in HSCs or osteoclast precursors cause constitutive mTORC1 activation, impairing osteoclastogenesis.
The GPR171 pathway suppresses T cell activation and limits …
Oct 6, 2021 · Our study here demonstrated that GPR171 is inducible in T cells of both human and mouse, and GPR171 engagement by BigLEN inhibits TCR-mediated signaling cascades, …
T cell Receptor Signal Transduction in T lymphocytes - PMC
Engagement of the TCR triggers the formation of multi-molecular signalosomes that lead to the generation of second messengers and subsequent activation of multiple distal signaling …
An expanded role of the tumor suppressor TSC1 in T cell tolerance
Nov 1, 2012 · The tumor suppressor TSC1, in association with TSC2, inhibits the activation of the mammalian target of rapamycin complex 1 (mTORC1) via the GAP activity of the TSC1/2 …
Nuclear factor of activated T-cell c3 inhibition of mammalian …
We identified REDD1, a negative regulator of mammalian target of rapamycin (mTOR) through the tuberous sclerosis complex (TSC1/2 complex), as a new molecular target of NFATc3.
NFAT proteins: key regulators of T-cell development and function
Jun 1, 2005 · Experimental evidence indicates that, during T-cell development, calcium–calcineurin–NFAT signalling is a key regulator of positive selection. NFAT2 and …
mTORC1 induces plasma membrane depolarization and promotes ...
Mar 8, 2022 · We found that mTORC1 accelerated preosteoblast senescence in vitro and in a mouse model. Mechanistically, mTORC1 induced a change in the membrane potential from …
New opportunities to overcome T cell dysfunction: the role of ...
Sep 13, 2024 · In the context of T cell dysfunction, the interaction of NFAT with AP-1 is attenuated, resulting in diminished effector gene expression and the interaction of NFAT with …
Tumor suppressor TSC1 is critical for T-cell anergy - PMC
Aug 8, 2012 · In this report, we demonstrate that TSC1 is critical for T-cell anergy by negative control of mTORC1. Its deficiency leads to cluster of differentiation (CD)28-independent …