Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by …

This chapter focuses on TRPM8, describing what was known about cold signaling before the channel was cloned, how TRPM8 was identified as a cold sensor, and what advances have …

Oct 18, 2023 · Melastatin-like transient receptor potential (TRPM) channels are multifunctional cation channels with diverse biophysical and physiological characteristics. Eight family …

Sep 5, 2020 · The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation channel that controls Ca 2+ homeostasis. It has been proposed to be the …

Transient Receptor Potential Melastatin 8 (TRPM8) is a member of the TRP ion channel family; its major physiological activator is cold, and it is also activated by “cooling agents” such as …

Transient receptor potential melastatin 8 (TRPM8) channels play a central role in the detection of environmental cold temperatures in the somatosensory system. TRPM8 is found in a subset of …

May 30, 2007 · The menthol receptor TRPM8 is a strong candidate as a cold transducer, but its physiological importance has been questioned. A study of cold sensitivity in TRPM8 knockout …

Sep 5, 2019 · Here, we present cryo–electron microscopy structures of TRPM8 in ligand-free, antagonist-bound, or calcium-bound forms, revealing how robust conformational changes give …

Sep 5, 2020 · Ion channels are important therapeutic targets due to their plethoric involvement in physiological and pathological consequences. The transient receptor potential cation channel …

Oct 19, 2023 · TRPM8 is a non-selective cation channel permeable to both monovalent and divalent cations that is activated by multiple factors, such as temperature, voltage, pressure, …