Transient receptor potential cation channel, subfamily C, member 6 or Transient receptor potential canonical 6, also known as TRPC6, is a protein encoded in the human by the TRPC6 gene.

Apr 26, 2018 · Here we present the structure of human TRPC6 homotetramer in complex with a newly identified high-affinity inhibitor BTDM solved by single-particle cryo-electron microscopy …

TRPC6 is a non-selective cation channel 6 times more permeable to Ca (2+) than to Na (+). Channel homotetramers heterologously expressed have a characteristic doubly rectifying …

TRPC6 N338S is a gain-of-function mutant identified in patient with doxorubicin-induced cardiotoxicity. Protein detection and localization of the non-selective cation channel TRPC6 in …

TRPCs are involved in the continually growing number of cell functions. Furthermore, mutations in the TRPC6 gene are associated with hereditary diseases, such as focal segmental …

Mutations in TRPC6, a member of the transient repeptor potential (TRP) superfamily of non-selective cation channels, have been identified as causing a familial form of focal segmental …

Mar 30, 2025 · TRPC6 (Transient Receptor Potential Cation Channel Subfamily C Member 6) is a Protein Coding gene. Diseases associated with TRPC6 include Focal Segmental …

Recent advances in cryogenic electron microscopy have provided several high-resolution structures of TRPC channels. Growing evidence demonstrates the involvement of TRPC …

Mar 17, 2023 · Transient receptor potential canonical type 6 (TRPC6) is a non-voltage-gated channel that principally conducts calcium. Elevated channel activation contributes to fibrosis, …

Here we report cryo-EM structures of TRPC6 in both antagonist-bound and agonist-bound states. The structures reveal two novel recognition sites for the small-molecule modulators …