Mar 1, 2018 · Human skin harbors two major T cell compartments of equal size that are distinguished by expression of the chemokine receptor CCR8. In vitro studies have …

These TRM express high levels of the cutaneous lymphocyte antigen (CLA) and specific chemokine receptors such as CCR4, and a proportion up-regulates the chemokine receptor …

Dec 2, 2019 · Here, we show that airway and interstitial T RM cells have distinct effector functions and that CXCR6 controls the partitioning of T RM cells within the lung by recruiting CD8 T RM …

Dec 1, 2022 · Skin TRM cells highly specifically express skin homing markers CLA, CCR4 and CCR6, while CCR8 and CXCR6 are expressed on about 50% of skin resident T cells [32]. …

Jul 4, 2023 · Collectively, our findings show that access to antigen presentation and strength of TCR-signaling required for Blimp1 expression establishes the chemotactic properties of …

Sep 22, 2021 · By using high-dimensional single-cell technologies, we identify heterogeneous behavior within the tissue-resident memory CD8+ T (Trm) cells infiltrating luminal-like tumors.

Here, we show that airway and interstitial T RM cells have distinct effector functions and that CXCR6 controls the partitioning of T RM cells within the lung by recruiting CD8 T RM cells to …

Aug 1, 2021 · TRM (CD8 +) cells secrete melanocyte damaging molecules like granzyme B, perforin & IFN-γ. Chemokine receptors CXCR3, CXCL9 & CXCL10 promote development & …

Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising …

CCR8 − skin T cells express genes associated with immune cell activation. In broad terms, the presence of CCR8 + and CCR8 − memory T cells in human skin could reflect either local …