Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KRAB-associated protein-1 (KAP1), is a protein that in humans is encoded by the TRIM28 gene.

Jan 16, 2025 · We show that CD8 + T-cell-specific deletion of Trim28 in mice disrupts autocrine IL-2 production and leads to impaired CD8 + T cell activation in vitro and in vivo. Mechanistically, TRIM28 binds...

Mar 30, 2025 · TRIM28 (Tripartite Motif Containing 28) is a Protein Coding gene. Diseases associated with TRIM28 include Wilms Tumor 1 and Wilms Tumor 5 . Among its related pathways are Gene expression (Transcription) and Infectious disease .

In this review, we summarize core biological functions of TRIM28 that emerge from TRIM28 multi-domain structure and possessed enzymatic activities. Moreover, we will discuss whether the complexity of TRIM28 engagement in cancer biology makes TRIM28 a possible candidate for targeted anti-cancer therapy.

TRIM28 is a multidomain protein with versatile functions in transcription and DNA repair. Recently it was shown that this factor plays unanticipated roles in transcriptional elongation.

Aug 29, 2017 · Here, we present distinct aspects of TRIM28 involvement in regulation of cancer cell homeostasis which collectively imply pro-tumorigenic character of TRIM28. Thorough analyses are further needed to verify whether TRIM28 possess the potential to become a new anti-cancer target.

Aug 1, 2023 · Using rapid immunoprecipitation and mass spectrometry (RIME) and co-immunoprecipitation, we identified TRIM28 (Tripartite motif containing 28) as a protein which complexes with ERα and PR in...

Feb 8, 2025 · TRIM28 Selective Nanobody Reduces Glioblastoma Stem Cell Invasion. TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation. Tripartite motif containing 28 (TRIM28) promotes the growth and migration of endometrial carcinoma cells by regulating the AKT/mTOR signaling pathway.

Jul 14, 2016 · TRIM28 regulates gene expression by affecting the transcriptional activity of KRAB-ZFP-specific loci, trans-repression or epigenetic modulation of chromatin structure.

Nov 5, 2024 · Our research has provided new and important insights into the crucial role of TRIM28 in maintaining protein homeostasis and its involvement in myeloma pathogenesis. TRIM28 activates the proteasome and autophagy pathways, making it a potential promising therapeutic target in MM.