The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) …

Mar 30, 2025 · TRAF5 (TNF Receptor Associated Factor 5) is a Protein Coding gene. Diseases associated with TRAF5 include Breast Cancer and Hematologic Cancer. Among its related pathways are BAFF in B-Cell Signaling and 4-1BB Pathway.

TRAF2 and TRAF5 therefore regulate diverse physiological roles, ranging from T and B cell signaling and inflammatory responses to organogenesis and cell survival. The major pathways mediated by TRAF2 and TRAF5 are the classical and alternative pathways of NF-κB activation, and MAPK and JNK activation.

Autoimmune encephalomyelitis TRAF5 has recently been recognized as a critical regulator of T H 17 development through multiple mechanisms. TRAF5 inhibits IL-6-induced early T H 17 development by directly interacting with gp130 and antagonizing the recruitment of STAT3 to gp130 in CD4+ T cells [172, 173].

TRAF5 promotes the occurrence and development of colon cancer via the activation of PI3K/AKT/NF-kappaB signaling pathways. Overexpression of miRNA-410-3p protects hypoxia-induced cardiomyocyte injury via targeting TRAF5.

Jan 1, 2014 · Following TLR stimulation, TRAF5 associated in a complex with the TLR adaptor protein MyD88 and the B cell-specific positive regulator of TLR signaling TAB2. Furthermore, TRAF5 negatively regulated the association of TAB2 with its signaling partner TRAF6 after TLR ligation in B cells.

Sep 3, 1996 · TRAF5 has a tumor necrosis factor receptor-associated factor (TRAF) domain in its carboxyl terminus and is most homologous to TRAF3, also known as CRAF1, CD40bp, or LAP-1, a previously identified CD40-associated factor.

Jun 21, 1996 · In vitro translated TRAF5 binds to the cytoplasmic region of the lymphotoxin-β receptor (LT-βR) but not to several other related receptors including CD40, both TNF receptors, Fas, and nerve growth factor receptor. TRAF5 and LT-βR coimmunoprecipitate when overexpressed in COS7 cells.

Feb 1, 2022 · TNF receptor-associated factor 5 (TRAF5) restrains early signaling activity of the IL-6 receptor in naive CD4 + T cells by interacting with the shared gp130 chain, although TRAF5 was initially discovered as a cytoplasmic adaptor protein to activate signaling mediated by TNF receptor family molecules.

Oct 17, 2011 · Tumor necrosis factor (TNF; 191160) receptor-associated factors (TRAFs), such as TRAF5, are signal transducers for members of the TNF receptor superfamily (see 191190).