TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene. [5] [6] [7] TRAF4 is a member of the …

Mar 30, 2025 · TRAF4 (TNF Receptor Associated Factor 4) is a Protein Coding gene. Diseases associated with TRAF4 include Lung Cancer and Intraneural Perineurioma. Among its related …

We identified TrkA, a neurotrophin receptor tyrosine kinase, as a TRAF4-targeted ubiquitination substrate that promotes prostate cancer cell invasion, and found that inhibition of TrkA activity …

TRAF4 functions as an adaptor signaling molecule in platelet receptor–mediated production of reactive oxygen species by directly interacting with two platelet receptors: GPIb-IX-V and …

Jun 13, 2013 · TRAF4 protein overexpression is limited to cancer cells and the subcellular localization is consistently cytoplasmic in a large majority of cases. Increased TRAF4 gene …

TRAF4. Unique among the TRAF family, TRAF4 is mainly involved in developmental, morphogenic, and oncogenic processes [148–153]. However, TRAF4 also regulates …

Jul 21, 2022 · Here we identified TRAF4 overexpression as one of the putative mechanisms for HER2-positive breast cancer cells to maintain HER2 signaling during Trastuzumab treatment, …

Feb 15, 2022 · TRAF4 is a crucial component that mediates pro-oncogenic transforming growth factor-β (TGF-β)-induced SMAD and non-SMAD signaling. TRAF4 is required for effective …

TRAF4 is an adapter protein overexpressed in certain cancers but its contributions to tumorigenesis are unclear. In lung cancer cells and primary lung tumors, we found that TRAF4 …

Feb 15, 2022 · Tumour necrosis factor receptor-associated factor 4 (TRAF4) is a member of the TRAF protein family, a cytoplasmic bridging molecule closely associated with various immune …