Feb 11, 2013 · Instead, thanks to the generation of an antibody specific for SUMO-modified c-Fos, we provide here direct evidence that SUMOylated c-Fos is present on a stably integrated reporter...

The fos/jun heterodimer binds to and activates transcription from TPA-responsive promoter elements (TGACTCA), which represent one final target of the protein kinase C pathway. The other main signal transduction pathway, initiated by the activation of the adenylate cyclase, involves the transcription factor CREB.

Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. [1] . AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis. [2] .

To our knowledge, this is the first report showing that transcription factor c-Fos mediates the TPA-induced COX-2 reactivation by recruiting KDM2A to the COX-2 promoter in human lung cancer cells.

Nov 1, 2005 · The Fos family of transcription factors includes c-Fos (the human homolog of the retroviral oncogene v-Fos), FosB, Fra-1 and Fra-2 as well as smaller FosB splice variants FosB2 and deltaFosB2.

In this review, we provide an overview of FOS and FOSB, including their functions and the differences between lesions with known FOS/FOSB gene rearrangements. Additionally, we discuss the use of FOS / FOSB immunohistochemistry as a diagnostic tool for these lesions.

Nov 1, 2008 · We found a marked synergistic activation of c-fos promoter by TPA and activated Ras oncogene. This synergy was mediated by SRE in the c-fos promoter. We also studied the role of PKC isoforms in those pathways.

PKC is a potent inhibitor of the steroidogenic enzyme CYP17. We have demonstrated that, in the ovary, PKC activates expression of FOS, a member of the AP-1 family, and increased expression of this gene is linked to CYP17 downregulation.

We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis.

Mar 13, 2000 · We find here that the FAP1 site contributes strongly to phorbol ester (TPA) and Erk MAP kinase activation of the c- fos enhancer and that both the p62 TCF and FAP1 sites are required for...