Tumor protein p63, typically referred to as p63, also known as transformation-related protein 63, is a protein that in humans is encoded by the TP63 (also known as the p63) gene. [5] [6] [7] [8]

Mar 30, 2025 · TP63 (Tumor Protein P63) is a Protein Coding gene. Diseases associated with TP63 include Adult Syndrome and Limb-Mammary Syndrome. Among its related pathways are …

The TP63 gene provides instructions for making a protein called tumor protein p63 (also known simply as p63). The p63 protein functions as a transcription factor, which means it attaches …

Jun 8, 2010 · The TP63-related disorders comprise six overlapping phenotypes: Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome (which includes Rapp-Hodgkin syndrome) …

Feb 8, 2025 · Title: TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2. Reciprocal inhibition …

TP73 and TP63 recently emerged as sharing overall architectural similarities with TP53. Phylogeny indicates that these three genes derive from a common ancestor, thus defining a …

p63, also known as Trp63 (transformation related protein 63), TP63 (tumor protein 63) or AIS (amplified in squamous cell carcinoma), is a member of the p53 family of transcription factors, …

TP63 is a master regulator of cell differentiation and plays a vital role in developmental control [64,65,66]. However, little is known about the specific mechanism of developmental control by …

Feb 1, 2007 · TAp63 shows clear pro-apoptotic activity, mediated both by death receptors (CD95, TNF, TRAIL) and mitochondrial (bax, puma) pathways. Conversely, DeltaNp63 protects from …

TP63 is a master regulator that plays an essential role in epidermal differentiation. It is also a lineage-dependent oncogene in SCC. ΔNp63α is the prominent isoform of TP63 expressed in …