Jan 21, 2025 · A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and growth of tumors. A gene that has been coined "the guardian of the genome," when inactivated, it can also play a role in the persistence, growth, and spread of a …

The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation. [5] TP53 gene encodes proteins that bind to DNA and regulate gene expression to prevent mutations of the genome. [ 12 ]

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.

Mar 30, 2025 · TP53 (Tumor Protein P53) is a Protein Coding gene. Diseases associated with TP53 include Li-Fraumeni Syndrome and Papilloma Of Choroid Plexus. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Autodegradation of …

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles …

Various mutations in the p53 tumor suppressor can occur in cancer. These have different “fingerprints” and may serve as biomarkers for distinct tumors and targeted therapies. Genetic variations in the tumor suppressor gene TP53 (OMIM #191117) contribute to …

Mar 26, 2025 · This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.

Most TP53 mutations fall into two broad categories. The first group of “DNA-contact” mutations consists of mutations in residues that are directly involved in DNA binding, such as R248Q and R273H. ... M2 gene expression was significantly increased in M2-polarized macrophages from p53-mutant mice and p53-deficient . Mutant p53 also induces ...

Feb 9, 2025 · Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms.

Also called p53 gene and tumor protein p53 gene. A gene that makes a protein that is found inside the nucleus of cells and plays a key role in controlling cell division and cell death. Mutations (changes) in the TP53 gene may cause cancer cells to grow and spread in the body.