* TNKase may be prepared using a single 50-mg vial or two 25-mg vials. † From one 50-mg vial of TNKase reconstituted with 10 mL Sterile Water for Injection. Dosing in the ASSENT-2 trial was based on actual or estimated patient weights.

TNKase ® (tenecteplase) is a prescription medicine for use in adults: to reduce the risk of death associated with acute ST elevation myocardial infarction (STEMI).

TNKase (tenecteplase) is indicated for the treatment of acute ischemic stroke (AIS) in adults. Presence of intracranial conditions that may increase the risk of bleeding (eg, intracranial neoplasm, arteriovenous malformation, or aneurysm) TNKase is also contraindicated in patients for the treatment of AIS with:

Jan 8, 2025 · Vial Contents: The preservative-free single-use vial of TNKase contains 52.5 mg Tenecteplase, 0.55 g L-arginine, 0.17 g phosphoric acid, and 4.3 mg polysorbate 20, under partial vacuum.

Dec 10, 2001 · TNKase is a sterile, white to off-white, lyophilized powder for single intravenous (IV) bolus administration after reconstitution with Sterile Water for Injection (SWFI), USP. Each vial of TNKase...

Jun 25, 2023 · Tenecteplase (TNK) is a single-bolus recombinant fibrinolytic agent used to manage intravascular clots. The drug is in the tissue plasminogen activator (tPA) class of medications. FDA-approved indications include acute ST-elevation myocardial infarction (STEMI).

Mar 9, 2025 · TNKase is used to treat acute ischemic stroke (AIS) in adults or to reduce the risk of death associated with a heart attack (acute ST elevation myocardial infarction [STEMI]). TNKase may also be used for purposes not listed in this medication guide.

Each vial of TNKase nominally contains 52.5 mg Tenecteplase, 0.55 g L-arginine, 0.17 g phosphoric acid, and 4.3 mg polysorbate 20, which includes a 5% overfill. Each vial will deliver 50 mg of...

For injection: 25 mg or 50 mg as a white to pale yellow lyophilized powder in a single-dose vial for reconstitution with co-packaged Sterile Water for Injection, USP (diluent). 4 CONTRAINDICATIONS

Dec 18, 2024 · TNKase is for intravenous (IV) administration only, administered as a single bolus over 5 seconds. Individualize dosage based on the patient's weight (see Table 1). From one vial of TNKase reconstituted with 10 mL Sterile Water for Injection. Follow the below steps to prepare TNKase for administration: