Jun 7, 1999 · Here we report that the cytosolic adapter protein Grb2 is a novel binding partner of TNFR-I. Grb2 binds with its COOH-terminal SH3 domain to a PLAP motif within TNFR-I and with its NH2-terminal SH3 domain to SOS (son of sevenless).

Interestingly, TNF receptors have been found to interact with the Grb2 adaptor and son of sevenless (SOS) exchange factor (Hildt & Oess, 1999; Adam et al., 1996). Activated Grb2 binds through its SH3 domain to a motif within the TNF receptor, allowing this activated complex to stimulate c-Raf-1 kinase.

Jul 13, 2022 · In the present study, we found that rasfonin, a fungal natural product and an activator of necroptosis, enhanced Grb2 binding to receptor-interacting serine/threonine kinase 1 (RIP1), which plays...

To investigate the clinical importance of GRB2 in humans, we tested plasma GRB2 concentrations in healthy control recipients, patients with T2DM, and patients with T2DM coupled with CAS, and evaluated the relationship between GRB2 concentrations and anthropometric and metabolic variables.

Gab2 (Grb2-associated binder2) silencing or deficiency inhibits TNFα (tumor necrosis factor alpha)-induced, IL (interleukin)-1β–induced, or lipopolysaccharide (LPS)-induced proinflammatory responses in endothelial cells.

Dec 15, 2003 · Upregulated genes in the RA synovium included TNFR2, FLICE2, and signaling molecules involved in a MAP kinase pathway (GRB2, MAPK p38). In contrast, genes encoding SARP1 and various cell cycle regulators were down-regulated in the RA synovium relative to OA.

Jun 7, 1999 · Here we report that the cytosolic adapter protein Grb2 is a novel binding partner of TNFR-I. Grb2 binds with its COOH-terminal SH3 domain to a PLAP motif within TNFR-I and with its NH2-terminal...

In addition to interaction with phosphotyrosine via its SH2 domain, Grb2 is also associated with tumor necrosis factor (TNF- ) receptor I through one of its α SH3 domains, which results in...

Dec 15, 2003 · TNF-α-mediated induction of GRB2 and FLICE2 in RA FLS. FLS from 3-RA patients and 2-OA patients were stimulated with TNF-α and assayed using RT-PCR methods. The result of 1-RA and 1-OA FLS is shown as representative from two independent experiments.

Jun 7, 1999 · Here we report that the cytosolic adapter protein Grb2 is a novel binding partner of TNFR-I. Grb2 binds with its COOH-terminal SH3 domain to a PLAP motif within TNFR-I and with its NH 2-terminal SH3 domain to SOS (son of sevenless). …