TMPRSS2 protein's function in prostate carcinogenesis relies on overexpression of ETS transcription factors, such as ERG and ETV1, through gene fusion. TMPRSS2-ERG fusion …

Aug 22, 2023 · TMPRSS2 is an endothelial cell surface protein that is involved in the viral entry and spread of coronaviruses including severe acute respiratory syndrome coronavirus 2 …

Mar 30, 2025 · TMPRSS2 (Transmembrane Serine Protease 2) is a Protein Coding gene. Diseases associated with TMPRSS2 include Covid-19 and Prostate Cancer. Among its related …

Jun 8, 2022 · Transmembrane protease, serine 2 (TMPRSS2) has been identified as key host cell factor for viral entry and pathogenesis of SARS-CoV-2. Specifically, TMPRSS2 proteolytically …

Mar 26, 2025 · Gene target information for TMPRSS2 - transmembrane serine protease 2 (human). Find diseases associated with this biological target and compounds tested against it …

Jul 14, 2021 · It is important to consider strategies to target TMPRSS2 to control the SARS-CoV-2 infection and the pandemic 4 until a safe and effective vaccine against SARS-CoV-2 and its …

Oct 25, 2023 · We demonstrate that the transmembrane protease TMPRSS2 is a receptor for coronavirus HKU1; it triggers HKU1-mediated cell–cell fusion and viral entry by binding to both …

TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of the respiratory and gastrointestinal tract, the prostate, and other organs. Although the …

Jul 13, 2020 · Recent evidence suggested that SARS-CoV-2 uses the ACE2 receptor for cell entry, in synergy with the host’s TMPRSS2 [1]. More specifically, the viral S glycoprotein is …

Mar 28, 2022 · A small-molecule inhibitor of TMPRSS2 is effective against SARS-CoV-2 variants of concern in human lung cells and in donor-derived colonoids, and also shows prophylactic …