Toll-like receptor 5 (TLR5) is a pattern recognition receptor that specifically recognizes flagellin and consequently plays a crucial role in the control of intestinal homeostasis by activating innate and adaptive immune responses.

Jul 8, 2016 · Toll-like receptor 5 (TLR5) expression in the intestinal epithelial cells (IECs) is critical to maintain health, as underscored by multiple intestinal and extra-intestinal diseases in mice genetically engineered for IEC-specific TLR5 knockout.

Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. [5] It is a member of the toll-like receptor (TLR) family. TLR5 is known to recognize bacterial flagellin from invading mobile bacteria. [6]

Feb 6, 2013 · With TLR4, all three MAPK components were equally important, with TLR21, JNK and ERK signalling were dominant, whereas with TLR5, JNK was most important. In contrast, R848-induced TLR7 mRNA down regulation was dependent upon p38 and to a …

Nov 28, 2011 · Stimulation of TLR5 by flagellin is mediated through the signaling mediators MAPK p38 and ERK, which also were elevated in the monocytes of older compared with younger donors.

May 3, 2023 · Our new study presents results of screening of TLR5 TIR-derived decoy peptides and characterizes new peptides that suppress TLR signaling. Cell-permeable peptides were screened for TLR5 inhibition using HEK-Blue ™ -mTLR5 Cells stably transfected with mouse TLR5 (InvivoGen, San Diego, CA).

Using a multivariable mixed effect model, we report a highly significant increase in TLR5-induced production of IL-8 from monocytes of older individuals (P < 0.0001). Elevated IL-8 is accompanied by increased expression of TLR5, both protein and mRNA, and by increased levels of TLR5-mediated phosphorylation of MAPK p38 and ERK.

Apr 11, 2012 · Luteolin protected the brain from the damage caused by pMCAO, and this effect may be through downregulation of TLR4, TLR5, NF-κB, p38MAPK and upregulation of ERK expression.

Apr 7, 2016 · We report a novel mechanism regulating Sp1/Sp3 swap at the TLR5 promoter, mediated through simultaneous modifications by dephosphorylation/ acetylation of Sp1 via PKC-dependent activation of serine/threonine (ser/thr) phosphatases and phosphorylation of Sp3 by PKC-δ-mediated ERK activation.

Sep 9, 2022 · Functional analysis indicated that overexpression of the rs2072493_N592S allele affected the activation of NF-κB and AP-1, which could be attributed to impaired phosphorylation of p38 and ERK. Overexpression of TLR5 N592S was associated with increased chemosensitivity in the H1299 cell line.