Specifically, this study is designed to examine the possibility of TLR4 as a candidate receptor interacted with G. atrum polysaccharide (PSG-1) and elucidate the role of reactive oxygen species (ROS) in PSG-1-induced tumor necrosis factor-α (TNF-α) …

Apr 28, 2011 · Here we demonstrate that engagement of a subset of Toll-like receptors (TLR1, TLR2 and TLR4) results in the recruitment of mitochondria to macrophage phagosomes and augments mROS production.

Dec 21, 2017 · Reactive oxygen species (ROS) contribute to the development of non-alcoholic fatty liver disease. ROS generation by infiltrating macrophages involves multiple mechanisms, including Toll-like...

Using mice lacking a functional toll-like receptor 4 (TLR4), we demonstrate that TLR4 and ROS work in concert to mediate microglia activation, where the contribution from each pathway is dependent on the concentration of LPS.

Apr 1, 2014 · Furthermore, TLR4 was demonstrated as the critical receptor for ROS production stimulated by PSG-1, evidenced by the inhibition effect of anti-TLR4 mAb on the ROS production. These facts inspired us to explore the role of ROS in TLR4-mediated downstream signaling pathway in respond to PSG-1.

May 21, 2020 · We found that autophagy and ROS were required for S.pn -induced NETs formation. Moreover, TLR4 partly mediated NETs formation in response to S.pn in vitro and in vivo during AOM. We also showed...

TLR4 stimulation also activates NADPH oxidase, increasing ROS production and thus ROS‐induced NF‐κB translocation. As a result of these signalling pathways, TLR4 stimulation causes the up‐regulation of pro‐inflammatory mediators, such as TNFα, IL‐6 and IL‐1β.

We demonstrated that TLR4 plays a pivotal role in regulating AngII-induced vascular ROS levels by inhibiting the expression and activity of the antioxidant enzyme ecSOD, as well as by activating NADPH oxidase, which enhances inflammation to facilitate the progression of …

Aug 31, 2015 · In the present study, we demonstrate that the TLR4- and TLR2-induced IRAK-ERK pathway cross-talks with p67phox-Nox-2 for ROS generation, thus regulating IL-1β transcription and processing in...

TLR4-lacking neutrophils showed a higher phagocytic activity in the basal state, they were preferentially engulfed by the microglia after stroke, and they produced less radical oxygen species (ROS) in the first stage of the inflammatory process.