Aug 22, 2024 · Among the ten human TLRs, TLR4 is particularly well known for its ability to detect lipopolysaccharides (LPS), a component of the Gram-negative bacterial cell wall. In addition to …

Here we review some of the most promising drugs and agents that have the potential to attenuate TLR-mediated inflammation, e.g., anti-LPS strategies that aim to neutralize LPS (synthetic anti …

In this commentary, we address new insights gained in recent years and comment on emerging work using a genetic approach to address the role of MEK1 in TLR4 mediated signaling as …

Sep 1, 2018 · Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the TLR4/PI3K/Akt/mTOR, Raf-1/MEK/ERK, and Keap1/Nrf2/HO-1 Signaling …

Oct 1, 2023 · TLR4 plays an important role in the occurrence and development of tumors through the immune system. TLR4 has two signaling pathways: MyD88 dependent and MyD88 …

Nov 15, 2024 · The LPS/TLR4 signaling pathway activates the NF-κB pathway, which regulates pro-inflammatory mediators like iNOS and COX2 by accelerating IκB phosphorylation and …

Toll-like receptor 4 (TLR4), also designated as CD284 (cluster of differentiation 284), is a key activator of the innate immune response and plays a central role in the fight against bacterial …

Our data suggest that SARS-CoV-2 S protein as well as SARS-CoV-2 virus particles bind DC-SIGN, which induces signaling via kinase Raf-1 suppressing TLR4 signaling. Thus, we have …

Mechanistically, upregulation of TLR4, NF-κb, and BAFF was involved. We concluded that TLR4/NF-κb/BAFF in macrophages might be a possible common autoimmune pathway that …

Nov 1, 2016 · Signaling pathways via TLR4 activate various transcription factors like NF-κB, AP1, STAT1, and IRFs. Inhibition of these targets and their upstream signaling molecules provide a …