Dec 12, 2017 · This work demonstrates the ability for LPS to activate macrophages through the TLR4-NOX2 axis, the reliance of macrophages on the TLR4-NOX2 axis for its functions, and …

We sought to better understand the role of the TLR4-NOX2 axis in macrophage activation during M. tuberculosis infection. Methods: THP-1 macrophages and PMA primed THP-1 …

NOX2-deficient macrophages promote effector T-cell activation, expansion as well as their preferential secretion of the pro-inflammatory cytokines IFN-γ and IL-17. These mechanisms …

Mar 28, 2010 · Here we report that TLR4 and TLR2 specifically activated the endoplasmic reticulum (ER) stress sensor kinase IRE1α and its downstream target, the transcription factor …

Dec 12, 2017 · Previous studies have shown that lipopolysaccharide (LPS), through TLR4, could activate macrophages, improve their bactericidal ROS production, and facilitate anti-infective …

Our results provide the first evidence that ROS from the Nox2 NADPH oxidase can contribute to regulating autophagy in host defense against bacteria. The association of TLR, Nox2 and …

Jul 1, 2021 · Inhibition of TLR4/TRAF6/NOX2 signaling pathway attenuate the ER stress response and alleviate VILI. In ventilation-induced lung injury (VILI), prolonged nonpathogen-mediated …

This work demonstrates the ability for LPS to activate macrophages through the TLR4-NOX2 axis, the reliance of macrophages on the TLR4-NOX2 axis for its functions, and may contribute to …

May 18, 2022 · TLR-dependent NOX-generated O 2 •– activates the MAPK signaling pathway and induces NF-κB translocation from the cytosol to the nucleus, where it promotes the synthesis …

May 21, 2008 · Stimulation of neutrophils with specific TLR ligands results in an increased phagocytosis, respiratory burst, and IL-8 production suggesting that TLR signaling plays a …