Tissue inhibitor of metalloproteinases 2 (TIMP2) is a gene and a corresponding protein. The gene is a member of the TIMP gene family. The protein is thought to be a metastasis suppressor .

TIMP-2 is expressed in post-mitotic neurons and promotes cell differentiation and neurite outgrowth , as the result of cell cycle arrest through decreased expression of cyclins B and D …

Mar 30, 2025 · TIMP2 (TIMP Metallopeptidase Inhibitor 2) is a Protein Coding gene. Diseases associated with TIMP2 include Conjunctivochalasis and Abdominal Aortic Aneurysm. Among …

Here, we outline the known roles of the most abundant TIMP, TIMP2, in pulmonary diseases but also discuss future perspectives in TIMP2 research that could impact the lungs. TIMP2 directly …

Jan 13, 2021 · We assessed the predictive value of urinary tissue inhibitor of metalloprotease-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) regarding the need for …

TIMP-2 and IGFBP7 are cell-cycle arrest proteins expressed in renal tubular cells during periods of cellular stress or injury. TIMP-2 inhibits matrix metalloproteinase (MMP) activity, and …

TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization. Neuronal TIMP2 regulates hippocampus-dependent …

Mar 1, 2005 · TIMP-2 maintains tissue homeostasis by first suppressing proliferation in response to angiogenic factors in quiescent tissues, and by suppressing protease activity in those …

Nov 2, 2023 · Here, we report that TIMP2 is highly expressed by neurons within the hippocampus and its loss drives changes in cellular programs related to adult neurogenesis and dendritic …

Sep 15, 2003 · The matrix metalloproteinase (MMP)-2 has a crucial role in extracellular matrix degradation associated with cancer metastasis and angiogenesis. The latent form, pro-MMP …