Mar 5, 2018 · As Tshr mutation in mice affect the expression of other thyroid specific genes 13,17, we sought to examine some of these genes essential for thyroid development.

A new preclinical model of GO has been established in female BALB/c mice. This mouse model was established via immunization with the human TSHR α subunit by electrotransfection of a plasmid expressing human TSHR.

Apr 25, 2024 · We successfully induced a GD + GO mouse model by a repeated co-injection of pcDNA3.1/IGF-1Rα and pcDNA3.1/TSHR-289 plasmids. Injection of pcDNA3.1/IGF-1Rα alone failed to induce GD. Co-injection of two plasmids induced more severe GD + GO than pcDNA3.1/TSHR-289 ( +) alone.

Apr 1, 2015 · In this study, we have extended the existing model of adenovirally induced TSHR immunization by using a novel protocol, in which regular injections are continued for 9 months, in order to permanently boost antibody production in mice.

Lu et al. used a special mouse model (TRβ PV / PV mice) that has a negative mutation (PV) of the thyroid hormone-β receptor (TRβ). These mice have elevated TSH and serum thyroid hormone levels, and they spontaneously develop FTC.

C.RF- Tshr (hyt/hyt) mice have a mutated thyroid-stimulating hormone receptor (TSHR), and, without thyroid hormone supplementation, these mice develop severe hypothyroidism.

Aug 16, 2012 · TSHR knockout (TSHR-KO) mice have small thyroid glands, and show severe hypothyroidism with no detectable thyroid hormone and elevated TSH . KO mice die within 1 week of weaning, unless fed a diet supplemented with thyroid hormone.

Sep 22, 2023 · Our data indicate that immunization of mice with THSR significantly (p ≤0.0001) increased CCL5 concentrations in the bone marrow (Figure 6A). Linsitinib inhibited CCL5 upregulation and almost normalized the amount of CCL5 in the bone marrow (Figure 6A).

Nov 18, 2024 · MiR374b is involved in the complex regulation of NAFLD lipid metabolism. Notably, miR374b activity is significantly elevated in a NAFLD mouse model; TSH promotes its expression via the TSHR.

Aug 6, 2018 · We have combined major histocompatibility complex–binding assays with immunization and tolerance induction experiments in HLA-DR3 transgenic mice to design apitopes (antigen-processing independent epitopes) derived from thyrotropin receptor (TSHR) for treatment of patients with Graves’ disease (GD).