Thrombospondin-1 (TSP1) Contributes to the …
May 4, 2015 · Thrombospondin-1 is a matricellular protein involved in the maintenance of vascular structure and homeostasis through the regulation of …
- Author: Zhenjie Liu, Stephanie Morgan, Jun Ren, Qiwei Wang, Douglas S. Annis, Deane F. Mosher, Jing Zhang, C...
- Publish Year: 2015
THBS1 in macrophage-derived exosomes exacerbates cerebral …
Feb 24, 2025 · Furthermore, THBS1 was significantly upregulated in plasma exosomes from AIS patients and was positively correlated with blood–brain barrier (BBB) damage markers MMP-9 …
Myeloid-Derived TSP1 (Thrombospondin-1) …
Oct 8, 2020 · Using RNA fluorescent in situ hybridization, we identified macrophages being the major source of TSP1 in human and mouse aneurysmal tissues, accounting for over 70% of cells that actively expressed Thbs1 mRNA.
Suppression of thrombospondin-1–mediated …
Jan 3, 2025 · Deletion of Thbs1 (Thbs1 KO) suppressed HSC inflammaging and restored clinically relevant defects associated with hematopoietic aging including loss of HSC self-renewal and myeloid-biased differentiation.
Invadopodia associated Thrombospondin-1 contributes to a post …
Oct 1, 2023 · Thrombospondin-1 (TSP1), the protein encoded by the THBS1 gene was localized in invadopodia, and increased thrombospondin-1 expression resulted in enhanced MMP-2 …
ECM stiffness-tuned exosomes drive breast cancer motility …
Dec 1, 2021 · Based on our findings, we propose a model wherein increased invasiveness on stiffer substrates is driven by qualitative and quantitative alterations in exosomes, with …
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Blockade of TSP-1/CD47 signal axis promotes donor …
Mar 21, 2025 · Cd47 −/− and Thbs1 −/− recipients showed enhanced formation of a vascular network in BM compared to WT recipients (Figures 5D and 5E), which was associated with a …
Thrombospondin 1 - Wikipedia
Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can …
The Role of Biomarkers in the Management of Colorectal Liver …
In a separate study of eight patients with CRLM, several extracellular matrix components were significantly upregulated in CRLM compared with the primary tumor, most notably THBS1, …
Ntsr1 contributes to pulmonary hypertension by …
In summary, our results reveal that Ntsr1-JAK2-STAT3-Thbs1 pathway can induce enhanced ER stress via ATF6 activation and increased PASMC proliferation and migration capacities, which can be mechanism of the …
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