Bioinformatic analyses have revealed the presence of three conserved motifs within the CTDs of RSHs: TGS, ACT and DC. The TGS motif (named after the presence in ThrRS, GTPases, and …

Jul 9, 2018 · Bioinformatic analyses have revealed the presence of three conserved motifs within the CTDs of RSHs: TGS, ACT and DC. The TGS motif (named after the presence in ThrRS, …

Jul 9, 2018 · RSH enzymes are characterized by an N-terminal enzymatic domain bearing distinct motifs for (p)ppGpp synthetase or hydrolase activity and a C-terminal regulatory domain (CTD) …

Jul 1, 2019 · The C-terminal regulatory part of many bacterial RSH proteins includes TGS (Threonyl-tRNA synthetase, GTPase, SpoT) and RRM (RNA recognition motif, previously …

RelSau primarily exists in a synthetase-OFF/hydrolase-ON state, the TGS motif within the CTD is required to activate (p)ppGpp synthesis under stringent conditions, which is crucial for the …

TGS: Threonyl-tRNA synthetase, GTPase, SpoT domain, RRM*: RNA recognition motif, both important for the E. coli RelA interaction with the ribosome. The latter lacks 4 out of 5 amino …

Jul 9, 2018 · The stringent response is characterized by (p)ppGpp synthesis resulting in repression of translation and reprogramming of the transcriptome. In Staphylococcus aureus, …

Jul 16, 2024 · Transcription factors (TFs) are proteins that bind to specific DNA regions and can activate or inhibit other genes, known as target genes (TGs).

TFs with a more specific binding motif (lower entropy of the TFBS motif) show a higher correlation with their TGs, and TFs with characteristic nucleotide compositions of their TFBS (higher ratio …

Apr 19, 2021 · In this study, we create a general model of transcription factor influence on gene expression by incorporating both cis and trans gene regulatory features. We describe a …