TGF-beta signaling has been shown to play an important role in EMT. In fact, adding TGF-beta to epithelial cells in culture is a convenient way to induce EMT in various epithelial cells.

Jun 30, 2020 · Transforming growth factor-β (TGF-β) promotes tumor invasion and metastasis by inducing epithelial-mesenchymal transition (EMT). EMT is often related with acquisition of stemness...

The main features of the epithelial-mesenchymal transition (EMT) induced by TGFβ are a switch from mainly cytokeratin to mainly vimentin intermediate filaments, the formation of actin stress fibers and an enhancement of cell migration.

Sep 30, 2014 · Epithelial cells can exhibit a type of plasticity called epithelial-to-mesenchymal transition (EMT), in which they transform from cells with tight contacts to neighboring cells and function as a barrier into motile cells that are not connected to their neighbors.

We found that during EMT, TGF-β induces activation of the mTOR/S6 kinase 1 pathway through PI3 kinase and Akt, resulting in increased protein synthesis and cell size.

Feb 25, 2016 · We show that TGF-β induces an epithelial-mesenchymal transition (EMT), generally considered a pro-tumorigenic event. However, in TGF-β-sensitive PDA cells, EMT becomes lethal by converting TGF-β-induced Sox4 from an enforcer of tumorigenesis into a promoter of apoptosis.

TGF-β and BMP Signaling in EMT. TGF-β signaling is the most well-characterized pathway that is known to induce EMT, and acts through various intracellular messengers.

Transforming growth factor-β (TGF-β) has roles in embryonic development, the prevention of inappropriate inflammation and tumour suppression. However, TGF-β signalling also regulates pathological epithelial-to-mesenchymal transition (EMT), inducing ...

In this review, we focus on the novel insights into the roles of TGF-β-induced EMT in cancer progression and the underlying mechanisms that enable TGF-β to activate this epithelial plasticity response at transcription, translation, and posttranslational levels.

Jun 5, 2019 · In this review, we will consider the role of TGF-β signaling in cell cycle arrest, apoptosis, EMT and cancer cell metastasis. In particular, we will highlight recent insights into the multistep and dynamically controlled process of TGF-β-induced EMT and the functions of miRNAs and long noncoding RNAs in this process.