Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa - tissue factor complex.

Tissue factor pathway inhibitor (TFPI) is an alternatively spliced anticoagulant protein that primarily dampens the initiation phase of coagulation before thrombin is generated. As such, TFPI’s actions are localized to cells expressing TF and to ...

An inhibitor of tissue factor-induced coagulation was rediscovered in the 1980’s and subsequently named tissue factor pathway inhibitor (TFPI). Three isoforms of TFPI are transcribed through alternative mRNA splicing: TFPIα, which contains an acidic ...

A promising target for restoring thrombin generation is tissue factor pathway inhibitor (TFPI), a multivalent Kunitz-type serine protease inhibitor that regulates tissue factor-induced coagulation via factor Xa-dependent feedback inhibition of the tissue factor-factor VIIa complex.

May 8, 2014 · Tissue factor (TF) pathway inhibitor (TFPI) is the primary inhibitor of the initiation of blood coagulation and modulates the severity of a wide variety of bleeding and clotting disorders.

Mar 30, 2025 · Complete information for TFPI gene (Protein Coding), Tissue Factor Pathway Inhibitor, including: function, proteins, disorders, pathways, orthologs, and expression.

Nov 24, 2015 · Tissue factor (TF) pathway inhibitor (TFPI) is an anticoagulant protein that inhibits early phases of the procoagulant response. Alternatively spliced isoforms of TFPI are differentially expressed by endothelial cells and human platelets and plasma.

Jan 1, 2012 · TFPI is a multivalent, Kunitz-type proteinase inhibitor, which, due to alternative mRNA splicing, is transcribed in three isoforms: TFPIalpha, TFPIdelta, and glycosyl phosphatidyl inositol (GPI)-anchored TFPIbeta.

TFPI is a multivalent Kunitz-type proteinase inhibitor that produces FXa-dependent feedback inhibition of the FVlla/TF catalytic complex, directly inhibits FXa, and suppresses TF-dependent cellular signaling (figure 2).

The major anticoagulant proteins identified in plasma are tissue factor pathway inhibitor (TFPI), protein C, protein S, antithrombin (AT), α2-macroglobulin, and the protein Z-dependent protease inhibitor.