Follicular helper T (Tfh) cells are identified as a subset of CD4 + T helper cells, which is specialized in helping B cells in the germinal center reaction. Tfh cells express high levels of CXCR5, PD-1, IL-21, and other characteristic markers.

Jun 22, 2020 · Follicular helper T cells (T FH) provide key signals to antigen-specific B cells for the development of germinal center B (B GC) cells 1, 2. CD4 + T cells receiving T FH inductive signals...

Thpok (encoded by Zbtb7b) is an upstream regulator of Bcl6 by binding to intron 1 of Bcl6, and genetic ablation of Zbtb7b (Zbtb7b fl/fl Ox40-Cre) in CD4 + T cells interfered with Bcl6 and Maf expression and T FH differentiation . Egr2 directly regulates Bcl6 expression and induces T …

Jan 1, 2025 · Our current review provides the molecular characteristics of human Tfh cells, the differentiation pathways of Tfh subsets, mechanisms by which Tfh subsets induce IgE and IgG4 production, and their clinical implications in allergy, malignancy, and IgG4-related disease.

Feb 1, 2024 · We clarified the role of infiltrating GC-Tfh cells in lesions with TLOs by analyzing CD3 + T cells in SGs from patients with IgG4-RD (n = 6) using scRNA-seq (10x Genomics, Pleasanton, Calif) to profile tissue-infiltrating CD4 + CXCR5 + Bcl6 + GC-Tfh cells.

Aug 29, 2023 · investigate CD4 1CXCR5 Bcl6 GC-Tfh cells in affected lesions from patients with IgG4-RD. Results: Infiltrating CD4 1CXCR5 Bcl6 Tfh cells were divided into 5 main clusters. We detected HLA 1granzyme K (GZMK1) Tfh cells with cytotoxicity-associated features in patients with IgG4-RD. We also observed abundant infiltrating

Oct 15, 2017 · In this study, we first showed that a large number of Tfh (CD3 + CD4 + CXCR5 +) cells characterized by high expression levels of BCL6, PD-1, and ICOS had infiltrated submandibular glands (SMGs) from patients with IgG4-related dacryoadenitis and sialadenitis (IgG4-DS) compared with SMGs from patients with head and neck cancer as controls ...

This review focuses on advances in our understanding of Bcl6-mediated gene regulation of T FH functions, and the modulation of T FH by other TFs. These advances may have important implications in deciphering how repressor TFs can regulate many immunological cell types.

Apr 6, 2015 · Here we defined the BCL6 cistrome in primary human germinal center Tfh cells to assess mechanisms of BCL6 regulation of CD4 T cells, comparing and contrasting BCL6 function in T and B cells. BCL6 primarily acts as a repressor in Tfh cells, and BCL6 binding was associated with control of Tfh cell migration and repression of alternative cell fates.

Sep 27, 2021 · Loss-of-function and gain-of-function experiments in CD4 + T cells revealed that BCL6 is required for T FH cell differentiation in vivo and for the development of germinal centres. Why did this...