Follicular helper T cells (also known as T follicular helper cells and abbreviated as T FH), are antigen-experienced CD4 + T cells found in the periphery within B cell follicles of secondary lymphoid organs such as lymph nodes, spleen and Peyer's patches, and are identified by their constitutive expression of the B cell follicle homing receptor ...

T follicular helper cells (Tfh) are a specialized subset of CD4 + T cells that were first identified in the human tonsil. They play a critical role in protective immunity helping B cells produce antibody against foreign pathogens.

Tfh cell differentiation is a multi-stage, multi-factorial process involving B cell lymphoma 6 (Bcl6) and other transcription factors. This article reviews understanding of Tfh cell biology, including their differentiation, migration, transcriptional regulation, and B cell help functions.

Tfh cells are the CD4 + T cells specialized for helping B cells. Bcl6 was identified as the Tfh lineage defining transcription factor 10 years ago. Crotty reviews the extensive progress made in understanding Tfh cells since then, including surprising roles of Tfh cells in a range of diseases.

Nov 24, 2023 · Tfh cells provide costimulatory signals and cytokines to B cells, promoting class switch recombination, somatic hypermutation, and affinity maturation. These signals also induce GC...

Jul 11, 2022 · TFH cells are essential in sustaining protective antibody responses necessary for pathogen clearance in infection and vaccine-mediated protection.

T follicular helper (Tfh) cells play a crucial role in orchestrating the humoral arm of adaptive immune responses. Mature Tfh cells localize to follicles in secondary lymphoid organs (SLOs) where they provide help to B cells in germinal centers ...

Apr 12, 2010 · In this review, we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation, the relationship of Tfh cells to other CD4 + T-cell lineages, and the...

Mar 20, 2009 · Follicular helper T (Tfh) cells are the class of effector T helper cells that regulates the step-wise development of antigen-specific B cell immunity in vivo. Deployment of CXCR5 + Tfh cells to B cell zones of lymphoid tissues and stable cognate interactions with B cells are central to the delivery of antigen-specific Tfh cell function.

Tfh cells are the CD4+ T cells specialized for helping B cells. Bcl6 was identified as the Tfh lineage-defining transcription factor 10 years ago. Crotty reviews the extensive progress made in understanding Tfh cells since then, including surprising roles of Tfh cells in a range of diseases.