The TEL-AML1 fusion protein of acute lymphoblastic leukemia ... - PubMed
Dec 3, 2015 · The t(12;21) translocation is the most common genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) and gives rise to the TEL-AML1 fusion gene. Many …
Identification and Modeling of TEL-AML1 (ETV6-RUNX1) …
Nov 19, 2010 · TEL-AML1 (ETV6-RUNX1), the product of t (12;21) translocation, is the most common cytogenetic abnormality in childhood cancer, and is detected in 25–30% of precursor …
TEL-AML1, Expressed from t(12;21) in Human Acute Lymphocytic …
Jul 15, 2002 · TEL-AML1 is expressed from the t (12;21) chromosomal translocation inB-precursor acute lymphocytic leukemia (ALL). Creation of the TEL-AML1fusion disrupts one …
The TEL-AML1 fusion protein of acute lymphoblastic leukemia
Apr 20, 2015 · Many studies on TEL-AML1 describe specific properties of the fusion protein, but a thorough understanding of its function is lacking. We exploited a pluripotent hematopoietic …
TEL-AML1, expressed from t(12;21) in human acute lymphocytic
Jul 15, 2002 · TEL-AML1 is expressed from the t (12;21) chromosomal translocation inB-precursor acute lymphocytic leukemia (ALL). Creation of the TEL-AML1fusion disrupts one …
Modeling first-hit functions of the t(12;21) TEL-AML1 …
TEL (ETV6)- AML1 (RUNX1), generated by the chromosomal translocation t (12;21) (p13;q22) (1, 2), is the most prevalent fusion gene in pediatric cancer, occurring in some 25% of childhood …
JCI - The TEL-AML1 leukemia fusion gene dysregulates the TGF …
Mar 16, 2009 · TEL (ETV6)-AML1 (RUNX1), generated by the t (12;21) chromosome translocation, is the most common chimeric fusion gene in childhood cancer, selectively …
The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B …
The reciprocal translocation t(12;21)(p13;q22), the most common structural genomic alteration in B-cell precursor acute lymphoblastic leukaemia in children, results in a chimeric transcription …
Role of the TEL-AML1 fusion gene in the molecular pathogenesis …
May 24, 2004 · We discuss here the prenatal origins of the TEL/AML1 translocation as an initiating mutation, the role of TEL-AML1 in cellular transformation and the molecular …
TEL-AML1 transgenic zebrafish model of precursor B cell acute ...
We demonstrate that TEL-AML1 induces a B cell differentiation arrest, and that leukemia development is associated with loss of TEL expression and elevated Bcl2 / Bax ratio.