The transcription factor IRF4 is essential for TCR affinity ... - Nature
Sep 22, 2013 · We found here that the transcription factor IRF4 was induced in a manner dependent on affinity for the T cell antigen receptor (TCR) and acted as a dose-dependent …
mTOR coordinates transcriptional programs and mitochondrial …
May 29, 2018 · Mechanistically, mTOR functions downstream of antigenic signals to drive IRF4 expression and mitochondrial metabolism, and accordingly, deletion of mitochondrial …
Interferon Regulatory Factor 4 Sustains CD8 - Cell Press
Nov 14, 2013 · IRF4 expression was regulated by T cell receptor (TCR) signaling strength via mammalian target of rapamycin (mTOR). Our data reveal that IRF4 translates differential …
IRF4 at the crossroads of effector T-cell fate decision
Apr 29, 2014 · In T cells, IRF4 is strongly induced within a few hours upon T-cell receptor (TCR) stimulation and its expression declines when the cells return to a resting state. As TCR …
The transcription factor IRF4 is essential for TCR affinity-mediated ...
We found here that the transcription factor IRF4 was induced in a manner dependent on affinity for the T cell antigen receptor (TCR) and acted as a dose-dependent regulator of the …
IRF4 expres-sion was regulated by T cell receptor (TCR) signaling strength via mammalian target of rapamycin (mTOR). Our data reveal that IRF4 translates differential strength of TCR …
IRF4 Provides Rations for Cytotoxic CD8+ T Cell Soldiers
Nov 14, 2013 · By using low- and high-affinity peptides, Yao et al. (2013) elegantly demonstrate that IRF4 expression in CD8 + T cells critically depended on the strength of the T cell receptor …
The Regulatory Effects of mTOR Complexes in the Differentiation …
Apr 23, 2020 · Ohtsubo et al. found that mTOR activity was needed for T cells to proliferate upon TCR/CD28-initiated stimuli or IL-2-dependent cell proliferation. Meanwhile, in these processes, …
Interferon regulatory factor 4 sustains CD8+ T cell expansion …
IRF4 expression was regulated by T cell receptor (TCR) signaling strength via mammalian target of rapamycin (mTOR). Our data reveal that IRF4 translates differential strength of TCR …
mTOR coordinates transcriptional programs and mitochondrial …
May 29, 2018 · Mechanistically, mTOR functions downstream of antigenic signals to drive IRF4 expression and mitochondrial metabolism, and accordingly, deletion of mitochondrial …