In humans, in 95% of T cells the TCR consists of an alpha (α) chain and a beta (β) chain (encoded by TRA and TRB, respectively), whereas in 5% of T cells the TCR consists of …

In this review, we examine the molecular basis for TCR activation in light of the recently determined cryoEM structure of a complete TCR–CD3 complex. This structure provides an …

Aug 28, 2019 · In this study, we report a cryo-electron microscopy (cryo-EM) structure of a human TCR–CD3 complex in its unliganded state at 3.7 Å resolution. The structure reveals the …

Apr 19, 2020 · Structure of T-cell receptor (TCR): The domain structure of αβ and Ƴ𝛿 TCR heterodimers are stringly similar to those of immunologlobins; thus they are classified as …

The T-cell receptor (TCR)-CD3 complex serves as a central paradigm for general principles of receptor assembly, ligand recognition, and signaling in the immune system.

Feb 11, 2020 · Here, we review TCR structural studies, in particular, antigen-induced conformational changes on the extracellular, transmembrane and intracellular domains. All of …

Mar 4, 2025 · Here, we leverage a large dataset of solved TCR structures from Immunocore to evaluate the current state-of-the-art for TCR structure prediction, and identify which regions of …

Apr 24, 2019 · Here we report a cryo-electron microscopy structure of human TCRαβ in complex with the CD3 hexamer at 3.7 Å resolution. The structure contains the complete extracellular …

Jan 24, 2020 · We review evidence from single-molecule and structural studies for force-induced conformational changes in the TCR-CD3 complex, for dynamically-driven TCR allostery, and …

Aug 29, 2024 · This article delves into the intricacies of TCR structure, function, signaling pathways, and testing methodologies, providing a comprehensive overview supported by the …